ArticleProceedings of the National Academy of Sciences of the United States of America2012
Contribution of cryoelectron microscopy of vitreous sections to the understanding of biological membrane structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy.Journal of microscopy · 2026Article
- Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Amorphous Calcium Carbonate Granules Form Within an Intracellular Compartment in Calcifying Cyanobacteria.Frontiers in microbiology · 2018Article
- In situ structural analysis of Golgi intracisternal protein arrays.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography.eLife · 2015Article
- Introduction of correlative light and airSEM™ microscopy imaging for tissue research under ambient conditions.Scientific reports · 2014Article
- Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast.Malaria journal · 2013Article
- Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ.Nature communications · 2013Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using cryoelectron microscopy of vitreous sections, we investigated in situ the ultrastructure of biological membranes, selected from several cell types for their diverse biological functions. Here we describe how to visualize the two membrane leaflets and tightly apposed membranes, lying as close as 1.1 nm apart, by tuning the imaging conditions. We show how defects in membrane stacks may be clues to resolving their structure. Details of membrane proteins are also resolved, as well as protein lattices with correlations between stacked membranes. Imaging the cell in its native hydrated state can now be done in the nanometer resolution range, which should open unique routes for investigating structure-function relationships.
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