ArticlePediatric pulmonology2013
Exhaled breath condensate purines correlate with lung function in infants and preschoolers.
Article in Pediatric pulmonology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of airway clearance therapies on mucociliary clearance in adults with cystic fibrosis: A randomized controlled trial.PloS one · 2022Trial
- Collecting exhaled breath condensate from non-ventilated preterm-born infants: a modified method.Pediatric research · 2022Article
- Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.Pediatric pulmonology · 2017Review
- Strategies for the etiological therapy of cystic fibrosis.Cell death and differentiation · 2017Review
- Metabolomic biomarkers predictive of early structural lung disease in cystic fibrosis.The European respiratory journal · 2016Article
- Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.Metabolites · 2015Review
- Determining urea levels in exhaled breath condensate with minimal preparation steps and classic LC-MS.Journal of chromatographic science · 2014Article
- Airway drug pharmacokinetics via analysis of exhaled breath condensate.Pulmonary pharmacology & therapeutics · 2014Article
- Novel end points for clinical trials in young children with cystic fibrosis.Expert review of respiratory medicine · 2013Review
- Exhaled breath condensate--from an analytical point of view.Biochemia medica · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAlthough airway inflammation begins early in life in children with chronic respiratory diseases, current methods to assess this inflammation are invasive and entail significant risk. Measurement of exhaled breath condensate (EBC) purines and other biomarkers offers a less invasive method to assess airway inflammation; however, the feasibility and utility of EBC biomarkers in young children has not been established.
methodsEBC was collected from children <3 years old with cystic fibrosis or other lung diseases during clinically indicated infant pulmonary function tests (iPFTs). EBC concentrations of the purine biomarkers adenosine (Ado), adenosine monophosphate (AMP), and the dilution marker urea were measured using mass spectrometry.
resultsEBC was successfully collected (average volume 330 ± 170 µl) from preschool children (age 2.3 ± 0.8 years) in 15 of 17 iPFTs. No significant changes in oxygen saturation (96.9 ± 1.6 start, 96.8 ± 1.7 end, P = 0.389) or respiratory rate (35.2 ± 7.5 start, 34.6 ± 7.9 end, P = 0.443) were observed during collection. Ado and AMP were successfully measured in 13/15 samples [8 cystic fibrosis (CF)]. EBC AMP to Ado ratio (AMP/Ado) negatively correlated with forced expiratory volume at 0.5 sec (FEV(0.5) , r = -0.71, P < 0.01) and positively with the ratio of residual volume to total lung capacity (RV/TLC, r = 0.66, P = 0.015). These correlations remained statistically significant in the subset with CF.
conclusionsEBC can be safely collected and analyzed in preschool children using commercially available equipment. The EBC AMP/Ado ratio correlates with measures of infant lung function and may be a less invasive means of monitoring airway inflammation in this population.
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