Evidence map›Paper›PMID 22614994›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012

Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors.

Wendy Demark-Wahnefried, Miriam C Morey, Richard Sloane, Denise C Snyder, Paige E Miller, Terryl J Hartman, Harvey J Cohen

4 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 133 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 21 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00303875 phase2completednot on this map

RENEW: Reach Out to Enhance Wellness in Older Survivors

TypeinterventionalSponsorDuke UniversityRan2003 to 2009Enrolled641ConditionsBreast Cancer, Colorectal Cancer, Prostate CancerArmsbehavioral dietary and exercise intervention
NCT02037542 nacompletednot on this mapstarted 2013, after this paper: background citation

A Study of Lifestyle Intervention in Overweight or Obese Women With Early Stage Breast Cancer

TypeinterventionalSponsorBaptist Health South FloridaRan2013 to 2016Enrolled100ConditionsWeightArmsDiet and exercise
NCT04297826 nacompletednot on this mapstarted 2021, after this paper: background citation

Expanding Our Cancer Prevention and Control Infrastructure to Reduce Cancer and Other Chronic Disease Health Disparities in the Deep South

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2021 to 2022Enrolled137ConditionsChronic DiseaseArmsHarvest for Health
NCT06002269 nacompletednot on this mapstarted 2024, after this paper: background citation

A Home-based Lifestyle Intervention for Optimizing Surgical Outcomes Among Urinary Bladder Cancer Patients: the BOOST Study

TypeinterventionalSponsorUniversity of UtahRan2024 to 2025Enrolled8ConditionsBladder Cancer, Cystectomy, ChemotherapyArmsDietary and Exercise Intervention
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 21 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
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  3. Effectiveness of Physical Activity Interventions among Rural Cancer Survivors: A Systematic Review and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
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  6. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
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  9. Dietary interventions for adult cancer survivors.The Cochrane database of systematic reviews · 2019
    Pooled it
  10. Systematic review and meta-analysis of maintenance of physical activity behaviour change in cancer survivors.The international journal of behavioral nutrition and physical activity · 2019
    Pooled it
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  13. A systematic review of psychosocial interventions for colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
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  18. Survivorship: healthy lifestyles, version 2.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014
    Guideline
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wendy Demark-WahnefriedUniversity of Alabama at Birmingham (UAB), Birmingham, AL, USA. demark@uab.edu
Miriam C Morey
Richard Sloane
Denise C Snyder
Paige E Miller
Terryl J Hartman
Harvey J Cohen
National Institutes of Health · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
Taste and smell enhancement in older cancer patientsP60AG011268 · NIA · DUKE UNIVERSITY · PI COHEN, HARVEY JAY · 1992 to 2005
$5.8M
RENEW Research-out to ENhancE Wellness Older SurvivorsR01CA106919 · NCI · DUKE UNIVERSITY · PI DEMARK-WAHNEFRIED, WENDY · 2004 to 2007
$2.1M
NCI NIH HHS R01 CA106919NCI NIH HHS R01CA106919NCRR NIH HHS UL1 RR024128NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS P60 AG011268
6 · The paper itself

Abstract

purposeDiet and exercise interventions have been tested in cancer survivors as a means to reduce late effects and comorbidity, but few have assessed adherence and health outcomes long term.

methodsBetween July 2005 and May 2007, the Reach Out to Enhance Wellness (RENEW) trial accrued 641 locoregionally staged, long-term (≥ 5 years from diagnosis) colorectal, breast, and prostate cancer survivors in the United States (21 states), Canada, and the United Kingdom. All participants were sedentary (< 150 minutes of physical activity [PA] a week), overweight or obese (body mass index, 25 to 40 kg/m(2)), and over age 65 years. The trial tested a diet-exercise intervention delivered via mailed print materials and telephone counseling. RENEW used a wait-list control, cross-over design (ie, participants received the year-long intervention immediately or after a 1-year delay), which allowed the opportunity to assess program efficacy (previously reported primary outcome), durability, and reproducibility (reported herein). Measures included diet quality (DQ), PA, BMI, and physical function (PF).

resultsNo significant relapse was observed in the immediate-intervention arm for DQ, PA, and BMI; however, rates of functional decline increased when the intervention ceased. From year 1 to year 2, significant improvements were observed in the delayed-intervention arm; mean change scores in behaviors and BMI and PF slopes were as follows: DQ score, 5.2 (95% CI, 3.4 to 7.0); PA, 45.8 min/wk (95% CI, 26.9 to 64.6 min/wk); BMI, -0.56 (95% CI, -0.75 to -0.36); and Short Form-36 PF, -1.02 versus -5.52 (P < .001 for all measures). Overall, both arms experienced significant improvements in DQ, PA, and BMI from baseline to 2-year follow-up (P < .001).

conclusionOlder cancer survivors respond favorably to lifestyle interventions and make durable changes in DQ and PA that contribute to sustained weight loss. These changes positively reorient functional decline trajectories during intervention delivery.

Indexed as

Health BehaviorAgedAged, 80 and overBody Mass IndexBody WeightCross-Over StudiesDietExerciseFemaleHumansMaleNeoplasmsObesitySurvivors

Identifiers

PMID22614994
PMCPMC3675693
OpenAlexW2102468400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.