ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012
Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor study.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05213936 (Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color), which is not on this map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color: A Clinical and Mechanistic Study
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Remote-Access Thyroidectomy in the Pediatric Population: a Systematic Review.Advances in therapy · 2023Pooled it
- Patient-Reported Outcome Instruments for Surgical and Traumatic Scars: A Systematic Review of their Development, Content, and Psychometric Validation.Aesthetic plastic surgery · 2016Pooled it
- A systematic review of selected musculoskeletal late effects in survivors of childhood cancer.Current pediatric reviews · 2014Pooled it
- Body image of patients in follow-up for pediatric bone sarcoma: implications of tumor location and local therapy.Journal of cancer survivorship : research and practice · 2026Article
- Psychosocial, Neuropsychological, Academic, and Social Outcomes in Pediatric Solid Tumor Survivors: An Exploratory Parent-Reported Study.Children (Basel, Switzerland) · 2026Article
- Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study.Pediatric blood & cancer · 2026Article
- Corrective and Restorative Dermatology in Cancer Survivors: An Urgent Unmet Need!American journal of clinical dermatology · 2026Review
- Article
- Social roles and emotional distress are associated with successful aging in adult childhood cancer survivors.Scientific reports · 2026Article
- 20-MHz high-intensity focused ultrasound for tattoo removal without pigment-specific optical targeting and with evidence for an ablation-associated transepidermal extrusion pathway.Frontiers in medicine · 2026Article
- Alopecia in Children with Cancer: A Review from Pathophysiology to Management.American journal of clinical dermatology · 2025Review
- Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-Versus-Host Disease Survivorship After Hematopoietic Cell Transplantation: Part IV. Patient Important Outcomes.Transplantation and cellular therapy · 2025Article
- Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Transoral endoscopic thyroidectomy using the vestibular approach in pediatric patients: 5-year experience in a single center in Vietnam.World journal of pediatric surgery · 2025Article
- Case Report: endoscopic thyroidectomy via total areola approach in a six-year-old patient with thyroid follicular adenoma.Frontiers in pediatrics · 2025Article
- Aesthetic Reconstruction of the Sequelae of Large Facial Involuted Infantile Hemangioma with Tissue Expanders.Aesthetic plastic surgery · 2024Article
- Bilateral axillo-breast approach robotic thyroglossal duct cyst resection in an adolescent: a case report and literature review.Gland surgery · 2024Article
- Robotic-assisted laparoscopy in pediatric surgical oncology: a narrative review.Translational pediatrics · 2023Review
- The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey.Clinical and translational radiation oncology · 2023Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeChildhood cancer survivors are at increased risk for adverse outcomes and chronic medical conditions. Treatment-related scarring, disfigurement, and persistent hair loss, in addition to their long-term impact on psychological distress or health-related quality of life (HRQOL), have received little attention. PATIENTS AND
methodsSelf-reported scarring/disfigurement and persistent hair loss were examined in 14,358 survivors and 4,023 siblings from the Childhood Cancer Survivor Study. Multivariable models were used to examine associations with demographic and cancer treatment. The impact of disfigurement and hair loss on HRQOL (ie, Medical Outcomes Short Form-36) and emotional distress (ie, Brief Symptom Inventory-18) was examined.
resultsSurvivors reported a significantly higher rate of scarring/disfigurement compared with siblings for head/neck (25.1% v 8.4%), arms/legs (18.2% v 10.2%), and chest/abdomen (38.1% v 9.1%), as well as hair loss (14.0% v 6.3%). In age-, sex-, and race-adjusted models, cranial radiation exposure ≥ 36 Gy increased risk for head/neck disfigurement (relative risk [RR], 2.42; 95% CI, 2.22 to 2.65) and hair loss (RR, 4.24; 95% CI, 3.63 to 4.95). Adjusting for cranial radiation, age, sex, race, education, and marital status, survivor hair loss increased risk of anxiety (RR, 1.60; 95% CI, 1.23 to 2.07), whereas head/neck disfigurement increased risk of depression (RR, 1.19; 95% CI, 1.01 to 1.41). Limitations due to emotional symptoms were associated with head/neck disfigurement (RR, 1.24; 95% CI, 1.10 to 1.41), arm/leg disfigurement (RR, 1.19; 95% CI, 1.05 to 1.35), and hair loss (RR, 1.26; 95% CI, 1.09 to 1.47).
conclusionSurvivors of childhood cancer are at increased risk for disfigurement and persistent hair loss, which is associated with future emotional distress and reduced quality of life. Future studies are needed to better identify and manage functional outcomes in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.