ReviewAnnals of nutrition & metabolism2012
Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.
Review in Annals of nutrition & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Oral Choline Reduced Working Memory-Related Brain Activation in Postmenopausal Women: A Pilot Study.Nutrients · 2026Trial
- Review
- Review
- Study on the correlation between homocysteine-related dietary patterns and gestational diabetes mellitus:a reduced-rank regression analysis study.BMC pregnancy and childbirth · 2022Article
- Proteomic identification of ruminal epithelial protein expression profiles in response to starter feed supplementation in pre-weaned lambs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration.International journal of molecular sciences · 2020Review
- Prolonging healthy aging: Longevity vitamins and proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018Review
- The Pediatric Methionine Requirement Should Incorporate Remethylation Potential and Transmethylation Demands.Advances in nutrition (Bethesda, Md.) · 2016Review
- Cow's milk allergy: towards an update of DRACMA guidelines.The World Allergy Organization journal · 2016Review
- Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.European journal of nutrition · 2015Observational
- Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats.Pharmacology, biochemistry, and behavior · 2015Article
- Nutrition: vitamins on trial.Nature · 2014Article
- Ruminal epithelium transcriptome dynamics in response to plane of nutrition and age in young Holstein calves.Functional & integrative genomics · 2014Article
- Big brains, meat, tuberculosis, and the nicotinamide switches: co-evolutionary relationships with modern repercussions?International journal of tryptophan research : IJTR · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create metabolic inefficiencies that alter the dietary requirement for, and responses to, nutrients. These SNPs can be detected using genetic profiling and the metabolic inefficiencies they cause can be detected using metabolomic profiling. Studies on the human dietary requirement for choline illustrate how useful these new approaches can be, as this requirement is influenced by SNPs in genes of choline and folate metabolism. In adults, these SNPs determine whether people develop fatty liver, liver damage and muscle damage when eating diets low in choline. Because choline is very important for fetal development, these SNPs may identify women who need to eat more choline during pregnancy. Some of the actions of choline are mediated by epigenetic mechanisms that permit 'retuning' of metabolic pathways during early life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.