ReviewNature reviews. Nephrology2012
The immunoregulatory function of vitamin D: implications in chronic kidney disease.
Review in Nature reviews. Nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.European journal of clinical nutrition · 2013Trial
- Bioactive metabolites: A clue to the link between MASLD and CKD?Clinical and molecular hepatology · 2025Review
- Vitamin D: A Bridge between Kidney and Heart.Life (Basel, Switzerland) · 2024Review
- Determining factors of functioning in hemodialysis patients using the international classification of functioning, disability and health.BMC nephrology · 2022Article
- Low serum vitamin D concentration is correlated with anemia, microinflammation, and oxidative stress in patients with peritoneal dialysis.Journal of translational medicine · 2021Article
- Factors of microinflammation in non-diabetic chronic kidney disease: a pilot study.BMC nephrology · 2020Article
- Article
- Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease.Scientific reports · 2019Article
- Article
- The impact of sunlight exposure on mortality of patients with end stage renal disease.Scientific reports · 2019Article
- Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 5/6 Nephrectomized Rats via Suppression of NF-κB Activation.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Biomarkers of Mineral and Bone Metabolism and 20-Year Risk of Hospitalization With Infection: The Atherosclerosis Risk in Communities Study.The Journal of clinical endocrinology and metabolism · 2017Article
- Review
- Effect of vitamin D level on the immunogenicity to hepatitis B vaccination in dialysis patients.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Observational
- Prevalence of Vitamin D Deficiency in Singapore: Its Implications to Cardiovascular Risk Factors.PloS one · 2016Article
- Serum 25-Hydroxyvitamin D Level Could Predict the Risk for Peritoneal Dialysis-Associated Peritonitis.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2015Article
- Effects of sun exposure and dietary vitamin D intake on serum 25-hydroxyvitamin D status in hemodialysis patients.Nutrition research and practice · 2015Article
- Article
- Vitamin D and the Immune System from the Nephrologist's Viewpoint.ISRN endocrinology · 2014Review
- Correlation of interleukin-17-producing effector memory T cells and CD4+CD25+Foxp3 regulatory T cells with the phosphate levels in chronic hemodialysis patients.TheScientificWorldJournal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Cardiovascular and infectious diseases remain the most common causes of death among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Basic science and epidemiological studies indicate that vitamin D has importance not only for cardiovascular health, but also for the immune response. Vitamin D signaling pathways regulate both innate and adaptive immunity, maintaining the associated inflammatory response within physiological limits. Levels of both the inactive as well as active form of vitamin D (25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, respectively) are decreased in patients with CKD and ESRD. It is reasonable to hypothesize, therefore, that the immune dysfunction associated with vitamin D deficiency in patients with CKD and ESRD in part explains the misdirected inflammatory response and increased susceptibility to infection seen in this population. Indeed, observational studies show that vitamin D deficiency in patients with ESRD is associated with increased mortality, and treatment with vitamin D is associated with a decreased risk of infection, as well as reduced all-cause mortality. However, whether different vitamin D preparations have differential effects on physiological function and clinical outcomes is still unclear. A proper understanding of the immune regulatory function of vitamin D is important for the development of future therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.