ReviewNature reviews. Gastroenterology & hepatology2012
What is personalized medicine and what should it replace?
Review in Nature reviews. Gastroenterology & hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.Pancreas · 2018Pooled it
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- Review
- The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis.Discover oncology · 2024Article
- Modalization and Transcendence of Health in the Coming Decade: Emphasizing the Human Cognitive System in the Stories of Prophets in the Holy Quran.Iranian journal of medical sciences · 2024Review
- A national framework for transition to precision medicine.Frontiers in medicine · 2024Article
- Personalized medicine approaches in cystic fibrosis related pancreatitis.American journal of translational research · 2022Article
- Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine.Frontiers in pediatrics · 2022Review
- Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD-Disease Outcome and Response to Therapy.Journal of Crohn's & colitis · 2021Review
- Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box.Communications biology · 2021Article
- Precision medicine for pancreatic diseases.Current opinion in gastroenterology · 2020Review
- Evaluation and Management of Suspected Early Chronic Pancreatitis (ECP).Current gastroenterology reports · 2020Review
- Anesthesiomics: Could a New Name Be Coined for Anesthesia?Anesthesiology and pain medicine · 2020Article
- Article
- Primer on Precision Medicine for Complex Chronic Disorders.Clinical and translational gastroenterology · 2019Article
- Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.Clinical and translational gastroenterology · 2019Review
- Fingerprinting Acute Digestive Diseases by Untargeted NMR Based Metabolomics.International journal of molecular sciences · 2018Article
- Deep Learning Methods for Predicting Disease Status Using Genomic Data.Journal of biometrics & biostatistics · 2018Article
- Personalized medicine in rheumatology: the paradigm of serum autoantibodies.Auto- immunity highlights · 2017Review
- Precision Medicine: Where have we reached and where are we headed?Sultan Qaboos University medical journal · 2017Article
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Abstract
Personalized medicine is a new framework for medical care that involves modelling and simulation of a disease on the basis of its underlying mechanisms. This strategy must replace the 20(th) century paradigm of defining disease by pathology or associated signs and symptoms and conducting outcomes research that is based on the presence or absence of the disease syndrome. New technologies, including next-generation sequencing, the 'omics' and powerful computers provide massive amounts of accurate data. However, attempts to understand complex disorders by applying these new technologies within the 20(th) century framework have failed to produce the expected medical advances. To help physicians embrace a paradigm shift, the limitations of the old framework and major advantages of the new framework must be demonstrated. Chronic pancreatitis is an ideal complex disorder to study to consider the pros and cons of the two frameworks, because the pancreas is such a simple organ for disease modelling, and the advantages of personalized medicine are so profound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.