Evidence map›Paper›PMID 22614726›Full record

ReviewIEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society2012

Cardiovascular genomics: a biomarker identification pipeline.

John H Phan, Chang F Quo, May Dongmei Wang

Abstract readReview
In one paragraph

Review in IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cardiovascular health informatics: risk screening and intervention.IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John H PhanDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. jhphan@gatech.edu
Chang F Quo
May Dongmei Wang

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI WANG, DONGMEI · 2005 to 2009
$18.4M
Nanotechnology: Detection &Analysis of Plaque FormationU01HL080711 · NHLBI · EMORY UNIVERSITY · PI BAO, GANG · 2005 to 2009
$11.0M
Nanotechnology Linking Biomarkers with Cancer BehaviorR01CA108468 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2008
$6.9M
NCI NIH HHS R01 CA108468NCI NIH HHS R01CA108468NCI NIH HHS U54 CA119338NCI NIH HHS U54CA119338NHLBI NIH HHS 5U01HL080711NHLBI NIH HHS U01 HL080711
6 · The paper itself

Abstract

Genomic biomarkers are essential for understanding the underlying molecular basis of human diseases such as cardiovascular disease. In this review, we describe a biomarker identification pipeline for cardiovascular disease, which includes 1) high-throughput genomic data acquisition, 2) preprocessing and normalization of data, 3) exploratory analysis, 4) feature selection, 5) classification, and 6) interpretation and validation of candidate biomarkers. We review each step in the pipeline, presenting current and widely used bioinformatics methods. Furthermore, we analyze several publicly available cardiovascular genomics datasets to illustrate the pipeline. Finally, we summarize the current challenges and opportunities for further research.

Indexed as

BiomarkersCardiovascular DiseasesCluster AnalysisGene Expression ProfilingGenomicsHumansOligonucleotide Array Sequence AnalysisBiomarkers

Identifiers

PMID22614726
PMCPMC5003026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.