ArticleInternational journal of colorectal disease2012
Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact?
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales.World journal of gastroenterology · 2016Pooled it
- Standardized Pathology Report for Colorectal Cancer, 2nd Edition.Journal of pathology and translational medicine · 2020Review
- Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemoradiotherapy: A comparison of morphological, volumetric and functional MRI parameters.European radiology · 2016Article
- Prognostic significance of tumor regression in lymph nodes after neoadjuvant therapy for rectal carcinoma.Virchows Archiv : an international journal of pathology · 2016Article
- Pathologic processing of the total mesorectal excision.Clinics in colon and rectal surgery · 2015Review
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Authors and funding
10 authors.
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Abstract
purposeNeoadjuvant treatment options have been developed to improve survival of patients with locally advanced rectal cancer. As only patients with a major histopatholocial response benefit from this preoperative therapy, several tumor regression grading systems have been developed. However, currently no accepted comprehensive grading system for clinical use is available. Therefore, we studied the impact of four histological regression grading systems in the neoadjuvant therapy of rectal cancer.
methodsIn this retrospective study, 85 patients with locally advanced rectal cancer were included. All patients received a neoadjuvant radiochemotherapy followed by surgical resection. The histological regression grading was evaluated using four classification systems: (1) grading system by the Japanese society of colorectal cancer, (2) grading system by Junker-Müller, (3) grading system by Dworak, (4) Cologne grading system. The four classification systems were analyzed for their prognostic impact.
resultsThe following significant correlations were detected between the four classification systems and the ypTNM categories: (1) patients with a ypT3/4 category had significantly more often a worse histopathologic response in all four grading systems (p = 0.001); (2) a ypN0 category was significantly correlated with good histopathologic response only in the Cologne grading system; (3) in the Junker-Müller and Dworak grading systems, a ypM0 category was significantly correlated with a good histopathologic response (p = 0.046; p = 0.03). However, none of the used classification systems had a prognostic impact on survival.
conclusionsCurrently, none of the analyzed histological regression grading systems is effective for clinical use.
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