Evidence map›Paper›PMID 22614634›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2012

Optimal designs for composed models in pharmacokinetic-pharmacodynamic experiments.

Holger Dette, Andrey Pepelyshev, Weng Kee Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Holger DetteFakultät für Mathematik, Ruhr-Universität Bochum, 44780 Bochum, Germany. holger.dette@ruhr-uni-bochum.de
Andrey Pepelyshev
Weng Kee Wong

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Promoting Hepatitis B Screening for Vietnamese American AdultsP01CA109091 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MAXWELL, ANNETTE · 2006 to 2010
$7.8M
Joining Forces with a Key Community to Reduce Obesity DisparitiesR24MD001762 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANCEY, ANTRONETTE K · 2005 to 2012
$4.7M
Cost Effective Designs for PractitionersR01GM072876 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, WENG K · 2005 to 2007
$666k
NCI NIH HHS P01 CA109091NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA16042-33NIGMS NIH HHS R01 GM072876NIGMS NIH HHS R01GM072876NIMHD NIH HHS R24 MD001762NIMHD NIH HHS R24MD001762
6 · The paper itself

Abstract

We consider two frequently used PK/PD models and provide closed form descriptions of locally optimal designs for estimating individual parameters. In a novel way, we use these optimal designs and construct locally standardized maximin optimal designs for estimating any subset of the model parameters of interest. We do this by maximizing the minimal efficiency of the estimates across all relevant parameters so that these optimal designs are less dependent on the individual parameter or parameters of interest. Additionally, robust designs are proposed to further reduce the dependence on the nominal values of the parameters. We compare efficiencies of our proposed optimal designs with locally optimal designs and designs used in four real studies from the literature and show that our proposed designs provide advantages over those used in practice.

Indexed as

Models, BiologicalPharmacokinetics

Identifiers

PMID22614634
PMCPMC4284081

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.