ReviewMolecular psychiatry2013
A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology.
Review in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Trial
- Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.Biological psychiatry global open science · 2026Article
- The Relation Between Parenting Stress and Children's Social Anxiety in Chinese Family: The Roles of Maladaptive Parenting and FKBP5 Gene Variation.Behavioral sciences (Basel, Switzerland) · 2026Article
- Yoga for Neurodegenerative Disorders: Therapeutic Effects, Mechanisms, and Applications in Alzheimer's and Parkinson's Disease.Sports (Basel, Switzerland) · 2025Review
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- Article
- The link between executive skills and neural dynamics during encoding, inhibition, and retrieval of visual information in the elderly.Human brain mapping · 2024Article
- Article
- The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease.IBRO neuroscience reports · 2022Review
- Person-identifying brainprints are stably embedded in EEG mindprints.Scientific reports · 2022Article
- Editorial: Decoding Brain Function Through Genetics.Frontiers in genetics · 2022Article
- Management and Treatment of Patients With Major Depressive Disorder and Chronic Diseases: A Multidisciplinary Approach.Frontiers in psychology · 2020Article
- Polymorphic variation in the SLC5A7 gene influences infant autonomic reactivity and self-regulation: A neurobiological model for ANS stress responsivity and infant temperament.Psychoneuroendocrinology · 2018Article
- Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.Biological psychiatry · 2018Review
- Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.British journal of pharmacology · 2017Review
- Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.Biological psychiatry · 2017Review
- Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.Psychoneuroendocrinology · 2017Article
- Adolescent neurobiological susceptibility to social context.Developmental cognitive neuroscience · 2016Review
- Genetics as a molecular window into recovery, its treatment, and stress responses after stroke.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
- Effects of early life stress on amygdala and striatal development.Developmental cognitive neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurogenetics research has begun to advance our understanding of how genetic variation gives rise to individual differences in brain function, which, in turn, shapes behavior and risk for psychopathology. Despite these advancements, neurogenetics research is currently confronted by three major challenges: (1) conducting research on individual variables with small effects, (2) absence of detailed mechanisms, and (3) a need to translate findings toward greater clinical relevance. In this review, we showcase techniques and developments that address these challenges and highlight the benefits of a neurogenetics approach to understanding brain, behavior and psychopathology. To address the challenge of small effects, we explore approaches including incorporating the environment, modeling epistatic relationships and using multilocus profiles. To address the challenge of mechanism, we explore how non-human animal research, epigenetics research and genome-wide association studies can inform our mechanistic understanding of behaviorally relevant brain function. Finally, to address the challenge of clinical relevance, we examine how neurogenetics research can identify novel therapeutic targets and for whom treatments work best. By addressing these challenges, neurogenetics research is poised to exponentially increase our understanding of how genetic variation interacts with the environment to shape the brain, behavior and risk for psychopathology.
Indexed as
Identifiers
22614291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.