ArticlePlant cell reports2012
Expression of phytochelatin synthase from aquatic macrophyte Ceratophyllum demersum L. enhances cadmium and arsenic accumulation in tobacco.
Article in Plant cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 99 citations in OpenAlex.
- Cadmium Is Accumulated as Electron-Dense Nanoparticles, Not Bound to Glutathione (GSH), Phytochelatins or Metallothioneins, and Extruded to the Culture Medium with GSH in the Marine AlgaInternational journal of molecular sciences · 2026Article
- Phytochelatins and Cadmium Mitigation: Harnessing Genetic Avenues for Plant Functional Manipulation.International journal of molecular sciences · 2025Review
- Copper Is Accumulated as Copper Sulfide Particles, and Not Bound to Glutathione, Phytochelatins or Metallothioneins, in the Marine AlgaInternational journal of molecular sciences · 2024Article
- A Green Approach Used for Heavy Metals 'Phytoremediation' Via Invasive Plant Species to Mitigate Environmental Pollution: A Review.Plants (Basel, Switzerland) · 2023Review
- Phytoremediation technologies and their mechanism for removal of heavy metal from contaminated soil: An approach for a sustainable environment.Frontiers in plant science · 2023Review
- Genetic diversity of the submerged macrophyteFrontiers in plant science · 2023Article
- Effects of Phytochelatin-like Gene on the Resistance and Enrichment of CdInternational journal of molecular sciences · 2022Article
- Heterologous Expression of the Phytochelatin SynthaseInternational journal of environmental research and public health · 2022Article
- Safe, efficient, and economically beneficial remediation of arsenic-contaminated soil: possible strategies for increasing arsenic tolerance and accumulation in non-edible economically important native plants.Environmental science and pollution research international · 2021Review
- Cadmium Accumulation Involves Synthesis of Glutathione and Phytochelatins, and Activation of CDPK, CaMK, CBLPK, and MAPK Signaling Pathways inFrontiers in plant science · 2021Article
- Overexpression ofFrontiers in plant science · 2021Article
- Heterologous expression of cyanobacterialPlant biotechnology reports · 2021Article
- Ancestral function of the phytochelatin synthase C-terminal domain in inhibition of heavy metal-mediated enzyme overactivation.Journal of experimental botany · 2020Article
- Genome-Wide Association Study of Cadmium Accumulation at the Seedling Stage in Rapeseed (Frontiers in plant science · 2018Article
- Phytoextraction of Heavy Metals: A Promising Tool for Clean-Up of Polluted Environment?Frontiers in plant science · 2018Review
- Overexpression of a FunctionalFrontiers in plant science · 2018Article
- Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance.Physiology and molecular biology of plants : an international journal of functional plant biology · 2017Review
- Aquatic Plant Genomics: Advances, Applications, and Prospects.International journal of genomics · 2017Review
- Horizontal Gene Transfer of Phytochelatin Synthases from Bacteria to Extremophilic Green Algae.Microbial ecology · 2017Article
- Overexpression of AtPCS1 in tobacco increases arsenic and arsenic plus cadmium accumulation and detoxification.Planta · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledPhytochelatin synthase (PCS), the key enzyme involved in heavy metal detoxification and accumulation has been used from various sources to develop transgenic plants for the purpose of phytoremediation. However, some of the earlier studies provided contradictory results. Most of the PCS genes were isolated from plants that are not potential metal accumulators. In this study, we have isolated PCS gene from Ceratophyllum demersum cv. L. (CdPCS1), a submerged rootless aquatic macrophyte, which is considered as potential accumulator of heavy metals. The CdPCS1 cDNA of 1,757 bp encodes a polypeptide of 501 amino acid residues and differs from other known PCS with respect to the presence of a number of cysteine residues known for their interaction with heavy metals. Complementation of cad1-3 mutant of Arabidopsis deficient in PC (phytochelatin) biosynthesis by CdPCS1 suggests its role in the synthesis of PCs. Transgenic tobacco plants expressing CdPCS1 showed several-fold increased PC content and precursor non-protein thiols with enhanced accumulation of cadmium (Cd) and arsenic (As) without significant decrease in plant growth. We conclude that CdPCS1 encodes functional PCS and may be part of metal detoxification mechanism of the heavy metal accumulating plant C. demersum. KEY MESSAGE: Heterologous expression of PCS gene from C. demersum complements Arabidopsis cad1-3 mutant and leads to enhanced accumulation of Cd and As in transgenic tobacco.
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