ArticleBMJ open2012
Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.
Article in BMJ open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers.International journal of experimental pathology · 2018Article
- Analysis of SNPs of MC4R, GNB3 and FTO gene polymorphism in obese Saudi subjects.African health sciences · 2017Article
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- Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents.Genes & diseases · 2017Article
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- Genomic research in Zambia: confronting the ethics, policy and regulatory frontiers in the 21st Century.Health research policy and systems · 2015Article
- Exploring genetic markers of adult obesity risk in black adolescent South Africans-the Birth to Twenty Cohort.Nutrition & diabetes · 2015Article
- Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans.European journal of human genetics : EJHG · 2015Article
- Novel locus for fibrinogen in 3' region of LEPR gene in island population of Vis (Croatia).Journal of human genetics · 2014Article
- Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.International journal of endocrinology · 2014Review
- The bigger picture of FTO: the first GWAS-identified obesity gene.Nature reviews. Endocrinology · 2014Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity is a complex trait with both environmental and genetic contributors. Genome-wide association studies have identified several variants that are robustly associated with obesity and body mass index (BMI), many of which are found within genes involved in appetite regulation. Currently, genetic association data for obesity are lacking in Africans-a single genome-wide association study and a few replication studies have been published in West Africa, but none have been performed in a South African population.
objectiveTo assess the association of candidate loci with BMI in black South Africans. The authors focused on single nucleotide polymorphisms (SNPs) in the FTO, LEP, LEPR, MC4R, NPY2R and POMC genes.
designA genetic association study.
participants990 randomly selected individuals from the larger Birth to Twenty cohort (a longitudinal birth cohort study of health and development in Africans). MEASURES: The authors genotyped 44 SNPs within the six candidate genes that included known BMI-associated SNPs and tagSNPs based on linkage disequilibrium in an African population for FTO, LEP and NPY2R. To assess population substructure, the authors included 18 ancestry informative markers. Weight, height, sex, sex-specific pubertal stage and exact age collected during adolescence (13 years) were used to identify loci that predispose to obesity early in life.
resultsSex, sex-specific pubertal stage and exact age together explain 14.3% of the variation in log(BMI) at age 13. After adjustment for these factors, four SNPs were individually significantly associated with BMI: FTO rs17817449 (p=0.022), LEP rs10954174 (p=0.0004), LEP rs6966536 (p=0.012) and MC4R rs17782313 (p=0.045). Together the four SNPs account for 2.1% of the variation in log(BMI). Each risk allele was associated with an estimated average increase of 2.5% in BMI.
conclusionsThe study highlighted SNPs in FTO and MC4R as potential genetic markers of obesity risk in South Africans. The association with two SNPs in the 3' untranslated region of the LEP gene is novel.
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