ArticleEcotoxicology (London, England)2012
Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas.
Article in Ecotoxicology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 33 citations in OpenAlex.
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- Molecular Identification, Characterization, and Expression Analysis of a Metallothionein Gene from Septifer virgatus.Marine biotechnology (New York, N.Y.) · 2020Article
- A Comparative Transcriptomics Approach to Analyzing the Differences in Cold Resistance inJournal of immunology research · 2020Article
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- Responses of primary cultured haemocytes derived from the marine gastropod Haliotis tuberculata to an industrial effluent exposure.Cytotechnology · 2017Article
- Mercury accumulation and its effects on molecular, physiological, and histopathological responses in the peacock blenny Salaria pavo.Environmental science and pollution research international · 2016Article
- Biomarkers assessment in the peacock blenny Salaria pavo exposed to cadmium.Environmental science and pollution research international · 2016Article
- Cadmium induced oxidative damage and apoptosis in the hepatopancreas of Meretrix meretrix.Ecotoxicology (London, England) · 2016Article
- Effects of Cu(2+) and Zn(2+) on growth and physiological characteristics of green algae, Cladophora.Environmental science and pollution research international · 2015Article
- Transcriptional response of stress-regulated genes to industrial effluent exposure in the cockle Cerastoderma glaucum.Environmental science and pollution research international · 2015Article
- Glutathione and its dependent enzymes' modulatory responses to toxic metals and metalloids in fish--a review.Environmental science and pollution research international · 2013Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequestration by metallothioneins and antioxidant defense are two kinds of important defense mechanisms employed by mollusks to minimize adverse effects caused by heavy metal contaminants in marine environment. In the present study, a novel metallothionein gene, CgMT-III, was cloned from Crassostrea gigas, consisting of eighteen conserved cysteine residues and encoding a MT III-like protein with two tandem β domains. The expression level of CgMT-III transcript induced by zinc was much higher than that induced by cadmium exposure. It suggested that CgMT-III was perhaps mainly involved in homeostatic control of zinc metabolism, which was distinct from previously identified MTs in C. gigas. Among the tested antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), SOD and GPx showed varying up-regulations in a tissue-specific manner, while CAT activities were inhibited in both gill and hepatopancreas from C. gigas exposed to heavy metals. It can be inferred that CgMT-III was mainly involved in zinc homeostasis, and CgMT-III gene together with CAT enzyme could be potential biomarkers to indicate heavy metal, especially zinc pollution in marine organisms.
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