ArticleBlood2012
Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.The New England journal of medicine · 2015Trial
- Pneumococcal vaccine hyporesponsiveness in people living with HIV: A narrative review of immunological mechanisms and insights from minimally invasive lymph node sampling.Human vaccines & immunotherapeutics · 2025Review
- Review
- Parotid preservation or immune protection? The dual dilemma in head and neck cancer radiotherapy.Frontiers in immunology · 2025Review
- Dynamic modulation of the non-canonical NF-κB signaling pathway for HIV shock and kill.Frontiers in cellular and infection microbiology · 2024Review
- Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging.Seminars in immunology · 2023Review
- Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses.European journal of immunology · 2021Review
- Lymph node stromal cells: cartographers of the immune system.Nature immunology · 2020Review
- The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences.iScience · 2019Review
- Antibody-Mediated CD4 Depletion Induces Homeostatic CD4Journal of virology · 2018Article
- Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer.Oncotarget · 2018Article
- Review
- A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression.PloS one · 2018Article
- Disrupted fibroblastic reticular cells and interleukin-7 expression in tumor draining lymph nodes.Oncology letters · 2017Article
- The Lymph Node in HIV Pathogenesis.Current HIV/AIDS reports · 2017Review
- Fibroblast reticular cells engineer a blastema extracellular network during digit tip regeneration in mice.Regeneration (Oxford, England) · 2017Article
- Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma.Frontiers in immunology · 2017Review
- A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.Pathogens & immunity · 2017Article
- Cardiovascular Disease, Statins, and HIV.The Journal of infectious diseases · 2016Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Loss of the fibroblastic reticular cell (FRC) network in lymphoid tissues during HIV-1 infection has been shown to impair the survival of naive T cells and limit immune reconstitution after antiretroviral therapy. What causes this FRC loss is unknown. Because FRC loss correlates with loss of both naive CD4 and CD8 T-cell subsets and decreased lymphotoxin-β, a key factor for maintenance of FRC network, we hypothesized that loss of naive T cells is responsible for loss of the FRC network. To test this hypothesis, we assessed the consequences of antibody-mediated depletion of CD4 and CD8 T cells in rhesus macaques and sooty mangabeys. We found that only CD4 T-cell depletion resulted in FRC loss in both species and that this loss was caused by decreased lymphotoxin-β mainly produced by the CD4 T cells. We further found the same dependence of the FRC network on CD4 T cells in HIV-1-infected patients before and after antiretroviral therapy and in other immunodeficiency conditions, such as CD4 depletion in cancer patients induced by chemotherapy and irradiation. CD4 T cells thus play a central role in the maintenance of lymphoid tissue structure necessary for their own homeostasis and reconstitution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.