ArticleBlood2012
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Can invariant Natural Killer T cells drive B cell fate? a look at the humoral response.Frontiers in immunology · 2025Review
- The Shaping of a B Cell Pool Maximally Responsive to Infections.Annual review of immunology · 2021Article
- Reading the room: iNKT cells influence B cell responses.Molecular immunology · 2021Review
- Invariant natural killer T cells balance B cell immunity.Immunological reviews · 2021Review
- SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function.International journal of molecular sciences · 2019Review
- SLAMF6 in health and disease: Implications for therapeutic targeting.Clinical immunology (Orlando, Fla.) · 2019Review
- The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.Frontiers in immunology · 2019Review
- Vaccine Designs Utilizing Invariant NKT-Licensed Antigen-Presenting Cells Provide NKT or T Cell Help for B Cell Responses.Frontiers in immunology · 2018Review
- EBV Infection in XLP1 Manifested Solely by Behavioral Aggression and Effective Treatment Using Rituximab.Case reports in immunology · 2018Article
- The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens.Frontiers in immunology · 2018Review
- Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B.Journal of leukocyte biology · 2017Article
- Innate immunity drives the initiation of a murine model of primary biliary cirrhosis.PloS one · 2015Article
- Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors.Frontiers in immunology · 2015Article
- Role and regulation of CD1d in normal and pathological B cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- The importance of B cell CD1d expression for humoral immunity.Expert review of vaccines · 2014Article
- Invariant NKT cells provide innate and adaptive help for B cells.Current opinion in immunology · 2014Review
- SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.Frontiers in immunology · 2014Article
- SAP modulates B cell functions in a genetic background-dependent manner.Immunology letters · 2013Article
- Article
- Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.Nature reviews. Immunology · 2013Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
One of the manifestations of X-linked lymphoproliferative disease (XLP) is progressive agammaglobulinemia, caused by the absence of a functional signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) in T, invariant natural killer T (NKT) cells and NK cells. Here we report that α-galactosylceramide (αGalCer) activated NKT cells positively regulate antibody responses to haptenated protein antigens at multiple checkpoints, including germinal center formation and affinity maturation. Whereas NKT cell-dependent B cell responses were absent in SAP(-/-).B6 mice that completely lack NKT cells, the small number of SAP-deficient NKT cells in SAP(-/-).BALB/c mice adjuvated antibody production, but not the germinal center reaction. To test the hypothesis that SAP-deficient NKT cells can facilitate humoral immunity, SAP was deleted after development in SAP(fl/fl).tgCreERT2.B6 mice. We find that NKT cell intrinsic expression of SAP is dispensable for noncognate helper functions, but is critical for providing cognate help to antigen-specific B cells. These results demonstrate that SLAM-family receptor-regulated cell-cell interactions are not limited to T-B cell conjugates. We conclude that in the absence of SAP, several routes of NKT cell-mediated antibody production are still accessible. The latter suggests that residual NKT cells in XLP patients might contribute to variations in dysgammaglobulinemia.
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Registered trials
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