ArticleOsteoarthritis and cartilage2012
High resolution micro arthrography of hard and soft tissues in a murine model.
Article in Osteoarthritis and cartilage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced μCT.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
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- Emerging targets in osteoarthritis therapy.Current opinion in pharmacology · 2015Review
- Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging.ACS nano · 2015Article
- Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics.Osteoarthritis and cartilage · 2014Article
- Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models.Journal of biomechanics · 2014Article
- Article
- 3D assessment of cortical bone porosity and tissue mineral density using high-resolution µCT: effects of resolution and threshold method.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Quantitative histological grading methods to assess subchondral bone and synovium changes subsequent to medial meniscus transection in the rat.Connective tissue researchArticle
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveRecent developments on high resolution micro computed tomography (μCT) allow imaging of soft tissues in small animal joints. Nevertheless, μCT images cannot distinguish soft tissues from synovial fluid due to their similar mass density, limiting the 3D assessment of soft tissues volume and thickness. This study aimed to evaluate a lead chromate contrast agent for μCΤ arthrography of rat knee joints ex vivo.
designIntact tibiofemoral rat joints were injected with the contrast agent at different concentrations and imaged using a μCT at 2.7 μm isotropic voxel size. Cartilage thickness was measured using an automated procedure, validated against histological measurements, and analyzed as a function of μCT image resolution. Changes in hard and soft tissues were also analyzed in tibiofemoral joints 4 weeks after surgical destabilization of the medial meniscus (DMM).
resultsThe contrast agent diffused well throughout the whole knee cavity without penetrating the tissues, therefore providing high contrast at the boundaries between soft tissues and synovial fluid space. Thickness analysis of cartilage demonstrated a high similarity between histology and μ-arthrography approaches (R(2) = 0.90). Four weeks after surgical DMM, the development of osteophytes (Oph) and cartilage ulcerations was recognizable with μCT, as well as a slight increase in trabecular bone porosity, and decrease in trabecular thickness.
conclusionsA lead chromate-based contrast agent allowed discriminating the synovial fluid from soft tissues of intact knee joints, and thus made possible both qualitative and quantitative assessment of hard and soft tissues in both intact and DMM tibiofemoral joints using high resolution μCT.
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