ArticleBrain, behavior, and immunity2013
Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: a replication and extension study.
Article in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 9 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Pooled it
- Chemotherapy-induced grey matter abnormalities in cancer survivors: a voxel-wise neuroimaging meta-analysis.Brain imaging and behavior · 2021Pooled it
- Prevalence of cognitive impairment and change in patients with breast cancer: A systematic review of longitudinal studies.Psycho-oncology · 2021Pooled it
- The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies.Neuropsychology review · 2020Pooled it
- Structural brain alterations following adult non-CNS cancers: a systematic review of the neuroimaging literature.Acta oncologica (Stockholm, Sweden) · 2019Pooled it
- Mindfulness-Based Stress Reduction on breast cancer symptoms: systematic review and meta-analysis.Einstein (Sao Paulo, Brazil) · 2018Pooled it
- Systematic review of self-reported cognitive function in cancer patients following chemotherapy treatment.Journal of cancer survivorship : research and practice · 2018Pooled it
- Causal relevance of circulating high-density lipoprotein cholesterol with cancer: a Mendelian randomization meta-analysis.Scientific reports · 2015Pooled it
- Association between apolipoprotein E genotype and cancer susceptibility: a meta-analysis.Journal of cancer research and clinical oncology · 2014Pooled it
- Assessing brain volume changes in older women with breast cancer receiving adjuvant chemotherapy: a brain magnetic resonance imaging pilot study.Breast cancer research : BCR · 2018Trial
- Trial
- Cognitive impairment after chemotherapy related to atypical network architecture for executive control.Oncology · 2015Trial
- Trial
- Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.Clinical breast cancer · 2013Trial
- Unveiling the cognitive fog in lung cancer patients: non-invasive exploration of blood-brain barrier disruption and brain structural changes.Annals of medicine · 2026Article
- Chemotherapy-Induced Brain Damage: Mechanisms and Insights from Rodent Models.Brain sciences · 2026Review
- Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026Review
- The effect of cancer and cancer treatment on attention control: evidence from anti-saccade performance.Journal of cancer survivorship : research and practice · 2026Article
- Longitudinal evaluation of hippocampal subfields volumes and episodic memory in breast cancer patients and healthy controls.Brain imaging and behavior · 2026Article
- Brain Functional and Structural Changes of Breast Cancer After Chemotherapy: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive changes related to cancer and its treatment have been intensely studied, and neuroimaging has begun to demonstrate brain correlates. In the first prospective longitudinal neuroimaging study of breast cancer (BC) patients we recently reported decreased gray matter density one month after chemotherapy completion, particularly in frontal regions. These findings helped confirm a neural basis for previously reported cognitive symptoms, which most commonly involve executive and memory processes in which the frontal lobes are a critical component of underlying neural circuitry. Here we present data from an independent, larger, more demographically diverse cohort that is more generalizable to the BC population. BC patients treated with (N=27) and without (N=28) chemotherapy and matched healthy controls (N=24) were scanned at baseline (prior to systemic treatment) and one month following chemotherapy completion (or yoked intervals for non-chemotherapy and control groups) and APOE-genotyped. Voxel-based morphometry (VBM) showed decreased frontal gray matter density after chemotherapy, as observed in the prior cohort, which was accompanied by self-reported difficulties in executive functioning. Gray matter and executive symptom changes were not related to APOE ε4 status, though a somewhat greater percentage of BC patients who received chemotherapy were ε4 allele carriers than patients not treated with chemotherapy or healthy controls. These findings provide confirmatory evidence of frontal morphometric changes that may be a pathophysiological basis for cancer and treatment-related cognitive dysfunction. Further research into individual risk factors for such changes will be critical for development of treatment and prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.