ArticleJournal of cardiac surgery2012
MRI-based multiparametric strain analysis predicts contractile recovery after aortic valve replacement for aortic insufficiency.
Article in Journal of cardiac surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Topographic mapping of left ventricular regional contractile injury in ischemic mitral regurgitation.The Journal of thoracic and cardiovascular surgery · 2017Article
- Preliminary investigation of multiparametric strain Z-score (MPZS) computation using displacement encoding with simulated echoes (DENSE) and radial point interpretation method (RPIM).Journal of magnetic resonance imaging : JMRI · 2016Article
- Quantifying "normalized" regional left ventricular contractile function in ischemic coronary artery disease.The Journal of thoracic and cardiovascular surgery · 2015Article
- Early left ventricular regional contractile impairment in chronic mitral regurgitation occurs in a consistent, heterogeneous pattern.The Journal of thoracic and cardiovascular surgery · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGuidelines for referral of chronic aortic insufficiency (AI) patients for aortic valve replacement (AVR) suggest that surgery can be delayed until symptoms or reduction in left ventricular (LV) contractile function occur. The frequent occurrence of reduced LV contractile function after AVR for chronic AI suggests that new contractile metrics for surgical referral are needed.
methodsIn 16 chronic AI patients, cardiac MRI tagged images were analyzed before and 21.5 ± 13.8 months after AVR to calculate LV systolic strain. Average measurements of three strain parameters were obtained for each of 72 LV regions, normalized using a normal human strain database (n = 63), and combined into a composite index (multiparametric strain z score [MSZ]) representing standard deviation from the normal regional average.
resultsPreoperative global MSZ (72-region average) correlated with post-AVR global MSZ (R(2) = 0.825, p < 0.001). Preoperative global MSZ also predicts improvement of impaired regions (N = 271 regions from 14 AI patients, R(2) = 0.392, p < 0.001). Preoperative MRI-based LV ejection fraction (LVEF) is also predictive (r = 0.410, p < 0.001). Although global preoperative MSZ had a significantly higher correlation than preoperative LVEF with improvement of injured regions (p < 0.001), both measures convey the same phenomenon.
conclusionsGlobal preoperative MRI-based multiparametric strain predicts global strain postoperatively, as well as improvement of regions (n = 72 per LV) with impaired contractile function. Global contractile function is an important correlate with improvement in regionally impaired contractile function, perhaps reflecting total AI volume-overload burden (severity/duration of AI).
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Registered trials
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