ArticleBritish journal of haematology2012
Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state.
Article in British journal of haematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Non-linear association between body mass index and port-related thrombosis in breast cancer patients: a retrospective cohort study.BMC cancer · 2026Article
- Obesity influences the biological response to injury: a multi-omics analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions.Metabolites · 2021Review
- Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children.International journal of molecular sciences · 2019Article
- Obesity is associated with postinjury hypercoagulability.The journal of trauma and acute care surgery · 2019Article
- Mendelian Randomisation study of the influence of eGFR on coronary heart disease.Scientific reports · 2016Article
- Obesity: physiologic changes and implications for preoperative management.BMC anesthesiology · 2015Review
- Obesity and dementia: adipokines interact with the brain.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Adipokines: a link between obesity and dementia?The Lancet. Neurology · 2014Review
- Portal vein thrombosis after laparoscopic splenectomy during childhood.Journal of thrombosis and thrombolysis · 2014Article
- Mechanisms of thrombosis in obesity.Current opinion in hematology · 2013Review
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8 authors at 1 institution in 1 country.
Funding
Abstract
Childhood obesity is rapidly increasing in prevalence. We compared circulating membrane-bound tissue factor (FIII, F3) procoagulant activity (TF-PCA) and plasma markers of coagulation, fibrinolysis and endothelial dysfunction in 21 obese (10·1 ± 1·5 years, mean ± standard deviation) and 22 healthy weight children (9·9 ± 1·6 years), classified by Body Mass Index (BMI). TF-PCA and factor VII coagulant activity (FVII:C), plasminogen activator inhibitor (PAI-1, SERPINE1) and soluble vascular cell adhesion molecule 1 (sVCAM1) were higher in obese children. BMI correlated positively with TF-PCA, FVII:C, and PAI-1. Childhood obesity is associated with a procoagulant state and endothelial dysfunction. Studies are needed to assess whether weight reduction reverses these abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.