ArticleACS combinatorial science2012
Solution-phase synthesis of a highly substituted furan library.
Article in ACS combinatorial science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Unified Approach to Furan Natural Products via Phosphine-Palladium Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
- Modular Synthesis of Furans with up to Four Different Substituents by a trans-Carboboration Strategy.Angewandte Chemie (International ed. in English) · 2020Article
- Solution-phase parallel synthesis of a multisubstituted cyclic imidate library.ACS combinatorial science · 2013Article
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Authors and funding
6 authors.
Funding
Abstract
A library of furans has been synthesized by iodocyclization and further diversified by palladium-catalyzed coupling processes. The key intermediate 3-iodofurans have been prepared by the electrophilic iodocyclization of 2-iodo-2-alken-1-ones in the presence of various nucleophiles in good to excellent yields under mild reaction conditions. These 3-iodofurans are the key components for library generation through subsequent elaboration by palladium-catalyzed processes, such as Suzuki-Miyaura, Sonagashira, Heck, aminocarbonylation, and carboalkoxylation chemistry to afford a diverse set of 2,3,4,5-tetrasubstituted furans.
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