ReviewSurgical infections2012
Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient.
Review in Surgical infections, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Disseminated nocardiosis in a patient with AIDS and B-cell non-Hodgkin's lymphoma: a case report.BMC infectious diseases · 2025Article
- A Rare Case of Coinfection ofInfection and drug resistance · 2025Article
- Bacteremia caused by Nocardia farcinica: a case report and literature review.BMC infectious diseases · 2024Review
- Article
- How an Antimicrobial Stewardship Team Treated a Nocardia farcinica-Associated Brain Abscess: A Case Report.Cureus · 2024Article
- Comparison of Clinical Characteristics and Treatment Outcome Between Localized and Disseminated Nocardiosis in a Tertiary Hospital in China.Infection and drug resistance · 2024Article
- Disseminated nocardiosis in a patient with alcoholic liver cirrhosis: a case report.BMC infectious diseases · 2023Article
- Pulmonary nocardiosis with bloodstream infection diagnosed by metagenomic next-generation sequencing in a kidney transplant recipient: A case report.World journal of clinical cases · 2023Article
- Disseminated Nocardiosis Caused byVeterinary sciences · 2022Article
- Immunoprotective Analysis of the NFA49590 Protein fromPathogens (Basel, Switzerland) · 2022Article
- Nocardia farcinica pituitary abscess in an immunocompetent patient: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Cerebellious abscesses caused by Nocardia farcinica in an immunocompromised patient.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Article
- Overlapping infection of Nocardia farcinica and Aspergillus fumigatus in a child with X-linked chronic granulomatous disease: a case report.BMC infectious diseases · 2022Article
- Nocardiosis: A two-center analysis of clinical characteristics.Frontiers in medicine · 2022Article
- Septic arthritis due toIDCases · 2022Article
- A case report of brain abscess caused by Nocardia farcinica.European journal of medical research · 2021Article
- Pleural Infection Caused by Nocardia farcinica: Two Cases and Review of the Literature.Cureus · 2021Article
- Primary Cutaneous Nocardiosis Due to Nocardia Farcinica: A Case Report of an Often Overlooked Infection.Infection and drug resistance · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNocardia farcinica is a gram-positive, partially acid-fast, methenamine silver-positive aerobic actinomycete. Nocardia spp. are opportunistic pathogens, and N. farcinica is the least common species of clinical importance.
methodsReview of the recent literature and description of a immunocompetent patient with no known risk factors who contracted fatal N. farcinica sepsis.
resultsPositive pre-mortem and post-mortem cultures from the lung and synovium correlated with acute bronchopneumonia and synovitis at autopsy. Colonies of filamentous bacteria, which were not apparent in conventional hematoxylin and eosin-stained sections, were observed with gram and methenamine silver stains, but acid-fast stains were negative. A literature review revealed that disseminated N. farcinica often is associated with an underlying malignant tumor or autoimmune disease (88% of patients). Chemotherapy or corticosteroid treatments are additional risk factors.
conclusionsTrimethoprim-sulfamethoxazole typically is the first-line therapy for N. farcinica; treatment with amikacin and imipenem-cilastatin is used less often (7% of patients). Despite aggressive therapy, we observed that the death rate (39%) associated with N. farcinica in recent publications was eight percentage points higher than reported in a review from 2000.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.