ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2013
MRS in early and presymptomatic carriers of a novel octapeptide repeat insertion in the prion protein gene.
Eric M McDade, Bradley F Boeve, Julie A Fields, Neeraj Kumar, Rosa Rademakers, Matt C Baker, Bsc David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it
What it found
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2 · The registry
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2 citing papers in PubMed, 2 citations in OpenAlex.
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5 · Who and what money
Authors and funding
10 authors at 2 institutions in 1 country.
Eric M McDadeDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Bradley F Boeve
Julie A Fields
Neeraj Kumar
Rosa Rademakers
Matt C Baker
Bsc David S Knopman
Ronald C Petersen
Clifford R Jack
Kejal Kantarci
Mayo Clinic in Florida · USUniversity of Pittsburgh · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI BU, GUOJUN · 1999 to 2018
$36.9M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
The Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
NEUROPSYCHOLOGY OF DEMENTIA WITH LEWY BODIESR01AG015866 · NIA · MAYO CLINIC JACKSONVILLE · PI FERMAN, TANIS JILL · 1999 to 2009
$2.6M
EXTRAMURAL RES FACIL IMPROVEMENT PROG: POLYCYSTIC KIDNEY DISEASE, RENAL STUDIES,C06RR018898 · NCRR · MAYO CLINIC · PI BURNETT, JOHN C · 2004 to 2004
$2.3M
Pathological basis of MRS and DTI changes in neurodegenerative dementiaR01AG040042 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2011 to 2015
$1.6M
Ethics of Surrogate Consent for Dementia ResearchR01AG029550 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, SCOTT Y · 2007 to 2010
$1.6M
Progranulin: Mutation and Regulation in Neurodegenerative diseaseR01NS065782 · NINDS · MAYO CLINIC JACKSONVILLE · PI RADEMAKERS, ROSA · 2009 to 2012
$1.3M
1H MRS markers of MCI syndromes and common dementiasK23AG030935 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2007 to 2009
To evaluate the proton magnetic resonance (MR) spectroscopy ((1) H MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at-risk mutation carriers and 13 controls were compared using single voxel, short TE, (1) H MRS from the posterior cingulate gyrus. The mutation carriers had an increased choline/creatine, P = .003 and increased myoinositol/creatine ratio, P = .003. (1) H MRS identified differences in markers of glial activity and choline metabolism in pre- and early-symptomatic carriers of a novel PRNP gene octapeptide insertion. These findings expand the possible diagnostic utility of (1) H MRS in familial prion disorders.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
MRS in early and presymptomatic carriers of a novel octapeptide repeat insertion in the prion protein gene. · full record | OpenQuestion