Evidence map›Paper›PMID 22611467›Full record

ArticleAmerican journal of translational research2012

Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.

Lei Nie, Hsing-Ju Wu, Jung-Mao Hsu, Shih-Shin Chang, Adam M Labaff, Chia-Wei Li, Yan Wang, Jennifer L Hsu, Mien-Chie Hung

Abstract read
In one paragraph

Article in American journal of translational research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed.

  1. Article
  2. LncRNA Knockdown Using Gapmer Antisense Oligonucleotides.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  9. H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer.The Yale journal of biology and medicine · 2023
    Review
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  19. Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei Nie
Hsing-Ju Wu
Jung-Mao Hsu
Shih-Shin Chang
Adam M Labaff
Chia-Wei Li
Yan Wang
Jennifer L Hsu
Mien-Chie Hung

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With rapid development of sequencing technologies such as deep sequencing and whole genome high-density tiling array, we now know that most of the "junk" genomic sequences are transcribed as non-coding RNAs (ncRNAs). A large number of long ncRNA transcripts (> 200bp) have been identified, and these long ncRNAs (LncRNAs) are found to be crucial regulators for epigenetic modulation, transcription, and translation. In this review, we briefly summarize the regulatory function of LncRNAs with a particular focus on the underlying mechanisms of LncRNAs in oncogenesis, tumor metastasis and suppression.

Indexed as

competitive endogenous RNA (ceRNA)epigenetic regulationLong non-coding RNA (LncRNA)natural antisense RNA (NAT)oncogenic lncRNApseudogene transcript

Identifiers

PMID22611467
PMCPMC3353529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.