ArticleInternational journal of cell biology2012
Potential role of drebrin a, an f-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: functional implications in epilepsy.
Article in International journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.International journal of molecular sciences · 2024Article
- The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.Scientific reports · 2021Article
- Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP ConsolidationFrontiers in synaptic neuroscience · 2017Article
- Drebrin and Spermatogenesis.Advances in experimental medicine and biology · 2017Article
- Drebrin inhibits cofilin-induced severing of F-actin.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Synaptic regulation of microtubule dynamics in dendritic spines by calcium, F-actin, and drebrin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Several neurological disorders characterized by cognitive deficits, including Alzheimer's disease, down syndrome, and epilepsy exhibit abnormal spine density and/or morphology. Actin-based cytoskeleton network dynamics is critical for the regulation of spine morphology and synaptic function. In this paper, I consider the functions of drebrin A in cell shaping, spine plasticity, and synaptic function. Developmentally regulated brain protein (drebrin A) is one of the most abundant neuron-specific binding proteins of F-actin and its expression is increased in parallel with synapse formation. Drebrin A is particularly concentrated in dendritic spines receiving excitatory inputs. Our recent findings point to a critical role of DA in dendritic spine structural integrity and stabilization, likely via regulation of actin cytoskeleton dynamics, and glutamatergic synaptic function that underlies the development of spontaneous recurrent seizures in pilocarpine-treated animals. Further research into this area may provide useful insights into the pathology of status epilepticus and epileptogenic mechanisms and ultimately may provide the basis for future treatment options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.