Evidence map›Paper›PMID 22610923›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012

Antiretroviral medication errors remain high but are quickly corrected among hospitalized HIV-infected adults.

Baligh R Yehia, Jimish M Mehta, Danielle Ciuffetelli, Richard D Moore, Paul A Pham, Joshua P Metlay, Kelly A Gebo

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. An Evaluation of Pharmacist-Led Interventions for Inpatient HIV-Related Medication Errors.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2019
    Article
  6. Article
  7. Review
  8. Article
  9. A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2015
    Review
  10. Article
  11. Graying of the HIV epidemic: a challenge for inpatient medicine providers.Journal of community hospital internal medicine perspectives · 2015
    Article
  12. Article
  13. Article
  14. Incidence of Antiretroviral Drug Interactions During Hospital Course: The Role of a Pharmacist-Led Antiretroviral Stewardship Program.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2014
    Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Baligh R YehiaDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104, USA. byehia@upenn.edu
Jimish M Mehta
Danielle Ciuffetelli
Richard D Moore
Paul A Pham
Joshua P Metlay
Kelly A Gebo
Hospital of the University of Pennsylvania · USJohns Hopkins University · USUniversity of Pennsylvania · USJohns Hopkins Medicine · US

Funding

North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
HIV DISEASE OUTCOMES IN DRUG USERS IN CLINICAL PRACTICER01DA011602 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 1998 to 2013
$10.8M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
Alcohol and HIV Treatment and Clinical ProgressionR01AA016893 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2008 to 2011
$1.3M
Neighborhood level determinants of pneumococcal disease transmissionK24AI073957 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI METLAY, JOSHUA P · 2008 to 2012
$1.0M
NIAAA NIH HHS R01 AA016893NIAAA NIH HHS R01 AA 16893NIAID NIH HHS K24 AI073957NIAID NIH HHS U01 AI069918NIDA NIH HHS K24 DA000432NIDA NIH HHS K24 DA 00432NIDA NIH HHS R01 DA011602NIDA NIH HHS R01DA11602
6 · The paper itself

Abstract

backgroundAntiretroviral therapy (ART) medication errors can lead to drug resistance, treatment failure, and death. Prior research suggests that ART medication errors are on the rise in US hospitals. This analysis provides a current estimate of inpatient antiretroviral prescribing errors.

methodsRetrospective review of medication orders during the first 48 hours of hospitalization for patients with human immunodeficiency virus (HIV) infection admitted to the Johns Hopkins Hospital between 1 January and 31 December 2009. Errors were classified as (1) incomplete regimen, (2) incorrect dosage, (3) incorrect schedule, and (4) nonrecommended drug-drug combinations. Multivariable regression was used to identify factors associated with errors.

resultsA total of 702 admissions occurred in 2009. Of these, 380 had ART medications prescribed on the first day and 308 on the second day of hospitalization. A total of 145 ART medication errors in 110 admissions were identified on the first day (29%), and 22 errors were identified in 21 admissions on the second day (7%). The most common errors were incomplete regimen and incorrect dosage or schedule. Protease inhibitors accounted for the majority of dosing and scheduling errors (71%-73%). Compared with patients admitted to the HIV/AIDS service, those admitted to surgical services were at increased risk of errors (adjusted odds ratio, 3.10; 95% confidence interval, 1.18-8.18).

conclusionsART medication errors are common among hospitalized HIV-infected patients on the first day of admission, but most are corrected within 48 hours. Interventions are needed to safeguard patients and prevent serious complications of ART medication errors especially during the first 24 hours of hospitalization.

Indexed as

AdolescentAdultAnti-Retroviral AgentsChi-Square DistributionHIV InfectionsHospitalizationHumansMaleMedication ErrorsMiddle AgedRetrospective StudiesAnti-Retroviral Agents

Identifiers

PMID22610923
PMCPMC3520383
OpenAlexW2128527413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.