ArticleArchives of women's mental health2012
A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype.
Article in Archives of women's mental health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction.Biological psychiatry · 2014Pooled it
- Estimating causal and time-varying effects of maternal smoking on youth smoking.Addictive behaviors · 2021Article
- Depressive Symptoms among Middle-Aged Women-Understanding the Cause.Brain sciences · 2020Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer's Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance.Molecular neurobiology · 2019Article
- Tobacco and cannabis use in college students are predicted by sex-dimorphic interactions between MAOA genotype and child abuse.CNS neuroscience & therapeutics · 2019Article
- Sex-Dimorphic Interactions ofFrontiers in genetics · 2019Article
- Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Interacting Effect of Catechol-Frontiers in psychology · 2018Article
- Does MAOA increase susceptibility to prenatal stress in young children?Neurotoxicology and teratology · 2017Article
- The role of monoamine oxidase A in aggression: Current translational developments and future challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Separating Family-Level and Direct Exposure Effects of Smoking During Pregnancy on Offspring Externalizing Symptoms: Bridging the Behavior Genetic and Behavior Teratologic Divide.Behavior genetics · 2016Article
- Prenatal tobacco exposure and self-regulation in early childhood: Implications for developmental psychopathology.Development and psychopathology · 2015Article
- The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review.Psychology research and behavior management · 2014Review
- Bringing a developmental perspective to anxiety genetics.Development and psychopathology · 2012Review
- The forensic use of behavioral genetics in criminal proceedings: Case of the MAOA-L genotype.International journal of law and psychiatryReview
- Do dopamine gene variants and prenatal smoking interactively predict youth externalizing behavior?Neurotoxicology and teratologyArticle
- Impact of prenatal exposure characterization on early risk detection: Methodologic insights for the HEALthy Brain and Child Development (HBCD) study.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
This study illustrates the application of a latent modeling approach to genotype-phenotype relationships and gene × environment interactions, using a novel, multidimensional model of adult female problem behavior, including maternal prenatal smoking. The gene of interest is the monoamine oxidase A (MAOA) gene which has been well studied in relation to antisocial behavior. Participants were adult women (N = 192) who were sampled from a prospective pregnancy cohort of non-Hispanic, white individuals recruited from a neighborhood health clinic. Structural equation modeling was used to model a female problem behavior phenotype, which included conduct problems, substance use, impulsive-sensation seeking, interpersonal aggression, and prenatal smoking. All of the female problem behavior dimensions clustered together strongly, with the exception of prenatal smoking. A main effect of MAOA genotype and a MAOA × physical maltreatment interaction were detected with the Conduct Problems factor. Our phenotypic model showed that prenatal smoking is not simply a marker of other maternal problem behaviors. The risk variant in the MAOA main effect and interaction analyses was the high activity MAOA genotype, which is discrepant from consensus findings in male samples. This result contributes to an emerging literature on sex-specific interaction effects for MAOA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.