Evidence map›Paper›PMID 22610405›Full record

ArticleMolecules and cells2012

Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ.

Deokbum Park, Youngmi Kim, Hyunah Kim, Kyungjong Kim, Yun-Sil Lee, Jongseon Choe, Jang-Hee Hahn, Hansoo Lee, Jongwook Jeon, Chulhee Choi and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 169 citations in OpenAlex.

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  17. CD44, ACAN, PLVAP, and HBEGF Emerged as Potential Biomarkers in Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Deokbum ParkSchool of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200-701, Korea.
Youngmi Kim
Hyunah Kim
Kyungjong Kim
Yun-Sil Lee
Jongseon Choe
Jang-Hee Hahn
Hansoo Lee
Jongwook Jeon
Chulhee Choi
Young-Myeong Kim
Dooil Jeoung
Kangwon National University · KRKorea Advanced Institute of Science and Technology · KREwha Womans University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronic acid (HA) has been shown to promote angiogenesis. However, the mechanism behind this effect remains largely unknown. Therefore, in this study, the mechanism of HA-induced angiogenesis was examined. CD44 and PKCδ were shown to be necessary for induction of the receptor for HA-mediated cell motility (RHAMM), a HA-binding protein. RHAMM was necessary for HA-promoted cellular invasion and endothelial cell tube formation. Cytokine arrays showed that HA induced the expression of plasminogen activator-inhibitor-1 (PAI), a downstream target of TGFβ receptor signaling. The induction of PAI-1 was dependent on CD44 and PKCδ. HA also induced an interaction between RHAMM and TGFβ receptor I, and induction of PAI-1 was dependent on RHAMM and TGFβ receptor I. Histone deacetylase 3 (HDAC3), which is decreased by HA via rac1, reduced induction of plasminogen activator inhibitor-1 (PAI-1) by HA. ERK, which interacts with RHAMM, was necessary for induction of PAI-1 by HA. Snail, a downstream target of TGFβ signaling, was also necessary for induction of PAI-1. The down regulation of PAI-1 prevented HA from enhancing endothelial cell tube formation and from inducing expression of angiogenic factors, such as ICAM-1, VCAM-1 and MMP-2. HDAC3 also exerted reduced expression of MMP-2. In this study, we provide a novel mechanism of HA-promoted angiogenesis, which involved RHAMM-TGFβRI signaling necessary for induction of PAI-1.

Indexed as

Angiogenesis Inducing AgentsAnimalsCells, CulturedExtracellular Matrix ProteinsExtracellular Signal-Regulated MAP KinasesHistone Deacetylase 3Histone DeacetylasesHumansHuman Umbilical Vein Endothelial CellsHyaluronan ReceptorsHyaluronic AcidMaleMatrix Metalloproteinase 2MiceMice, Inbred BALB CNeovascularization, PhysiologicAngiogenesis Inducing AgentsCD44 protein, humanExtracellular Matrix ProteinsExtracellular Signal-Regulated MAP KinasesHistone Deacetylase 3Histone Deacetylaseshyaluronan-mediated motility receptorHyaluronan ReceptorsHyaluronic AcidMatrix Metalloproteinase 2Mmp2 protein, mouseNeuropeptidesPlasminogen Activator Inhibitor 1Protein Kinase C-deltarac1 GTP-Binding ProteinRac1 protein, mouserac GTP-Binding ProteinsReceptors, Transforming Growth Factor betaTranscription Factor AP-1Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouse

Identifiers

PMID22610405
PMCPMC3887750
OpenAlexW2158766228

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.