ArticleMolecules and cells2012
Overexpression of Arabidopsis translationally controlled tumor protein gene AtTCTP enhances drought tolerance with rapid ABA-induced stomatal closure.
Article in Molecules and cells, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 84 citations in OpenAlex.
- Article
- Morphological, physiological, and transcriptomic analysis ofFrontiers in plant science · 2026Article
- Article
- StTCTP Positively RegulatesInternational journal of molecular sciences · 2025Article
- Long-Distance Movement ofPlants (Basel, Switzerland) · 2023Article
- Does translationally controlled tumor protein (TCTP) have the potential to produce crops with increased growth and tolerance to environmental stresses?Plant cell reports · 2023Article
- Article
- Controlling the Gate: The Functions of the Cytoskeleton in Stomatal Movement.Frontiers in plant science · 2022Review
- Green Light Partial Replacement of Red and Blue Light Improved Drought Tolerance by Regulating Water Use Efficiency in Cucumber Seedlings.Frontiers in plant science · 2022Article
- Protein Kinase Activity of Phytochrome A Positively Correlates With Photoresponses in Arabidopsis.Frontiers in plant science · 2021Article
- Morpho-Physiological and Proteomic Response of Bt-Cotton and Non-Bt Cotton to Drought Stress.Frontiers in plant science · 2021Article
- Translational regulation contributes to the elevated COThe Plant journal : for cell and molecular biology · 2020Article
- Barley Root Proteome and Metabolome in Response to Cytokinin and Abiotic Stimuli.Frontiers in plant science · 2020Article
- A Guard Cell Abscisic Acid (ABA) Network Model That Captures the Stomatal Resting State.Frontiers in physiology · 2020Article
- Article
- Changes in Proteome and Protein Phosphorylation Reveal the Protective Roles of Exogenous Nitrogen in Alleviating Cadmium Toxicity in Poplar Plants.International journal of molecular sciences · 2019Article
- Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling.PLoS computational biology · 2019Article
- Systemic signalling through translationally controlled tumour protein controls lateral root formation in Arabidopsis.Journal of experimental botany · 2019Article
- Identification of phosphorylation proteins in response to water deficit during wheat flag leaf and grain development.Botanical studies · 2018Article
- The Two Translationally Controlled Tumor Protein Genes,Frontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translationally controlled tumor protein (TCTP), also termed P23 in human, belongs to a family of calcium- and tubulin-binding proteins, and it is generally regarded as a growth-regulating protein. Recently, Arabidopsis TCTP (AtTCTP) has been reported to function as an important growth regulator in plants. On the other hand, plant TCTP has been suggested to be involved in abiotic stress signaling such as aluminum, salt, and water deficit by a number of microarray or proteomic analyses. In this study, the biological functions of AtTCTP were investigated by using transgenic Arabidopsis plants overexpressing AtTCTP. Interestingly, AtTCTP overexpression enhanced drought tolerance in plants. The expression analysis showed that AtTCTP was expressed in guard cells as well as in actively growing tissues. Physiological studies of the overexpression lines showed increased ABA- and calcium-induced stomatal closure ratios and faster stomatal closing responses to ABA. Furthermore, in vitro protein-protein interaction analysis confirmed the interaction between AtTCTP and microtubules, and microtubule cosedimentation assays revealed that the microtubule binding of AtTCTP increased after calcium treatment. These results demonstrate that the overexpression of AtTCTP confers drought tolerance to plants by rapid ABA-mediated stomatal closure via the interaction with microtubules in which calcium binding enhances the interaction. Collectively, the present results suggest that the plant TCTP has molecular properties similar to animal TCTPs, such as tubulin- and calcium-binding, and that it functions in ABA-mediated stomatal movement, in addition to regulating the growth of plants.
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