ReviewPharmaceutical research2012
Impact of excipient interactions on drug bioavailability from solid dosage forms.
Review in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 90 citations in OpenAlex.
- Simple Hydrodynamic Molecular Weight Model for Rapid Assessment of Therapeutic Protein Oligomerization States in Formulation.The AAPS journal · 2026Article
- Detection of cancer epigenetic alterations in a pilot cohort of workers exposed to TiOFrontiers in toxicology · 2026Article
- Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing.Drug delivery and translational research · 2025Article
- Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance.Communications chemistry · 2023Article
- Evaluation of Excipient Risk in BCS Class I and III Biowaivers.The AAPS journal · 2022Review
- Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.Pharmaceutics · 2021Article
- Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.The AAPS journal · 2021Article
- Solubility, Permeability, and Dissolution Rate of Naftidrofuryl Oxalate Based on BCS Criteria.Pharmaceutics · 2020Article
- Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties: Case Study-Hypromellose (HPMC).The AAPS journal · 2020Article
- Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability.Drug delivery and translational research · 2018Article
- Solid-State NMR Investigation of Drug-Excipient Interactions and Phase Behavior in Indomethacin-Eudragit E Amorphous Solid Dispersions.Pharmaceutical research · 2018Article
- Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug.Pharmaceutical research · 2015Article
- Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets.BioMed research international · 2015Article
- Commonly used excipients modulate UDP-glucuronosyltransferase 2b7 activity to improve nalbuphine oral bioavailability in humans.Pharmaceutical research · 2014Article
- Comparison study of oral iron preparations using a human intestinal model.Scientia pharmaceuticaArticle
- More Vigilance on Generic Drugs are Necessary.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excipients are generally pharmacologically inert, but can interact with drugs in the dosage form and the physiological factors at the site of absorption to affect the bioavailability of a drug product. A general mechanistic understanding of the basis of these interactions is essential to design robust drug products. This paper focuses on drug-excipient interactions in solid dosage forms that impact drug bioavailability, the drug substance and drug product properties affected by excipients, and the impact of excipients on physiologic processes. The extent to which drug bioavailability is affected by these interactions would vary on a case-by-case basis depending upon factors such as the potency and dose of the drug, therapeutic window, site of absorption, rate limiting factor in drug absorption (e.g., permeability or solubility limited), or whether drug metabolism, efflux, complexation, or degradation at the site of absorption play a role in determining its bioavailability. Nonetheless, a mechanistic understanding of drug-excipient interactions and their impact on drug release and absorption can help develop formulations that exhibit optimum drug bioavailability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.