ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Nitrite anion stimulates ischemic arteriogenesis involving NO metabolism.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.British journal of pharmacology · 2023Article
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling.Comprehensive Physiology · 2019Review
- Aerobic training and l-arginine supplementation promotes rat heart and hindleg muscles arteriogenesis after myocardial infarction.Journal of physiology and biochemistry · 2016Article
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Cystathionine γ-lyase regulates arteriogenesis through NO-dependent monocyte recruitment.Cardiovascular research · 2015Article
- Sodium nitrite provides angiogenic and proliferative effects in vivo and in vitro.Medical science monitor basic research · 2015Article
- Cellular and pharmacological targets to induce coronary arteriogenesis.Current cardiology reviews · 2014Review
- Control of angiogenesis dictated by picomolar superoxide levels.Free radical biology & medicine · 2013Article
- Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction.Frontiers in immunology · 2013Article
- Beets, bacteria, and blood flow: a lesson of three Bs.Circulation · 2012Article
- Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.Journal of the American Heart Association · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Nitric oxide (NO) is a potential regulator of ischemic vascular remodeling, and as such therapies augmenting its bioavailability may be useful for the treatment of ischemic tissue diseases. Here we examine the effect of administering the NO prodrug sodium nitrite on arteriogenesis activity during established tissue ischemia. Chronic hindlimb ischemia was induced by permanent unilateral femoral artery and vein ligation. Five days postligation; animals were randomized to control PBS or sodium nitrite (165 μg/kg) therapy twice daily. In situ vascular remodeling was measured longitudinally using SPY angiography and Microfil vascular casting. Delayed sodium nitrite therapy rapidly increased ischemic limb arterial vessel diameter and branching in a NO-dependent manner. SPY imaging angiography over time showed that nitrite therapy enhanced ischemic gracillis collateral vessel formation from the profunda femoris to the saphenous artery. Immunofluorescent staining of smooth muscle cell actin also confirmed that sodium nitrite therapy increased arteriogenesis in a NO-dependent manner. The NO prodrug sodium nitrite significantly increases arteriogenesis and reperfusion of established severe chronic tissue ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.