ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Article
- Review
- Gastric microbiota: an emerging player in gastric cancer.Frontiers in microbiology · 2023Review
- Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Curcumol Undermines SDF-1Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Anticancer Effects ofJournal of Cancer · 2021Article
- Review
- Analysis of Gene Expression of miRNA-106b-5p andGenes · 2020Article
- The Interplay between Two Transcriptional Repressors and Chaperones OrchestratesInternational journal of molecular sciences · 2018Review
- Transcriptome profiling of cancer tissues in Chinese patients with gastric cancer by high-throughput sequencing.Oncology letters · 2018Article
- Changes in patients' symptoms and gastric emptying after Helicobacter pylori treatment.World journal of gastroenterology · 2016Observational
- Proteomics-Based Identification and Analysis of Proteins Associated with Helicobacter pylori in Gastric Cancer.PloS one · 2016Article
- miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells.OncoTargets and therapy · 2015Article
- Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux.World journal of gastroenterology · 2014Article
- Role of cyclooxygenase-2 in gastric cancer development and progression.World journal of gastroenterology · 2013Review
- Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer.Virchows Archiv : an international journal of pathology · 2013Article
- Predicting a novel pathogenicity island in Helicobacter pylori by genomic barcoding.World journal of gastroenterology · 2013Article
- Anticancer effects of 4-vinyl-2,6-dimethoxyphenol (canolol) against SGC-7901 human gastric carcinoma cells.Oncology letters · 2013Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveApoptosis plays an important role in the regulation of gastric epithelial cell number and gastrointestinal disorders induced by Helicobacter pylori (Hp). Heat shock proteins (HSPs) are involved in cell integrity, cell growth and in gastric mucosa colonized by Hp. COX-2 was implicated in Hp-induced carcinogenesis but the effects of this germ and CagA cytotoxin on HSP70, COX-2, Bax and Bcl-2 in gastric cancer epithelial cells have been little studied. MATERIAL AND
methodsWe determined the expression for HSP70, Bax and Bcl-2 in human gastric epithelial MKN7 cells incubated with live strain Hp (cagA + vacA+) with or without co-incubation with exogenous CagA and NS-398, the selective COX-2 inhibitor. After 3-48 h of incubation, the expression of HSP70, COX-2, Bax and Bcl-2 mRNA and proteins were determined by RT-PCR and immunoprecipitation.
resultsHp inhibited expression for HSP70 and this was significantly potentiated by exogenous CagA. Co-incubation of epithelial cells with Hp, without or with CagA increased Bax expression and simultaneously decreased expression for Bcl-2. The increase in COX-2 mRNA and Bax expression were significantly inhibited by NS-398. We conclude that Hp promotes apoptosis in adenocarcinoma gastric epithelial cells in vitro and this is associated with activation of COX-2 and inhibition of HSP70.
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