ArticleHistochemistry and cell biology2012
Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat auditory organ morphogenesis.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Dynamic Interplay of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transitions in Cochlear Development and Disease: Molecular Mechanisms and Therapeutic Implications.Biomedicines · 2025Review
- Review
- Expression of S100β during mouse cochlear development.European journal of histochemistry : EJH · 2025Article
- Single-copy Snail upregulation causes partial epithelial-mesenchymal transition in colon cancer cells.BMC cancer · 2023Article
- Research progress in delineating the pathological mechanisms ofFrontiers in cellular neuroscience · 2023Review
- Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule.International journal of molecular sciences · 2022Article
- Epithelial-Mesenchymal Transition Participates in the Formation of Vestibular Flat Epithelium.Frontiers in molecular neuroscience · 2021Article
- Research progress on flat epithelium of the inner ear.Physiological research · 2020Review
- In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition.Nature communications · 2020Article
- EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions.iScience · 2019Article
- Epithelial-mesenchymal transition, and collective and individual cell migration regulate epithelial changes in the amikacin-damaged organ of Corti.Histochemistry and cell biology · 2017Article
- EMT and MET: necessary or permissive for metastasis?Molecular oncology · 2017Review
- miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer.Journal of cellular and molecular medicine · 2016Article
- Spatio-temporal dynamics of β-tubulin isotypes during the development of the sensory auditory organ in rat.Histochemistry and cell biology · 2015Article
- Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression.Biomedical reports · 2015Article
- Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival.Cancer research · 2015Article
- Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis.Frontiers in oncology · 2015Review
- The Histochemistry and Cell Biology compendium: a review of 2012.Histochemistry and cell biology · 2013Review
- Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells.Toxicology and applied pharmacology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epithelial-mesenchymal transition (EMT) plays a crucial role in the differentiation of many tissues and organs. So far, an EMT was not detected in the development of the auditory organ. To determine whether an EMT may play a role in the morphogenesis of the auditory organ, we studied the spatial localization of several EMT markers, the cell-cell adhesion molecules and intermediate filament cytoskeletal proteins, in epithelium of the dorsal cochlea during development of the rat Corti organ from E18 (18th embryonic day) until P25 (25th postnatal day). We examined by confocal microscopy immunolabelings on cryosections of whole cochleae with antibodies anti-cytokeratins as well as with antibodies anti-vimentin, anti-E-cadherin and anti-β-catenin. Our results showed a partial loss of E-cadherin and β-catenin and a temporary appearance of vimentin in pillar cells and Deiters between P8 and P10. These observations suggest that a partial EMT might be involved in the remodelling of the Corti organ during the postnatal stages of development in rat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.