Evidence map›Paper›PMID 22610066›Full record

ReviewBrain, behavior, and immunity2013

Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

Allison S Betof, Mark W Dewhirst, Lee W Jones

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 112 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 9 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01990430 naunknown statusnot on this map

Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients.

TypeinterventionalSponsorUniversidad Politecnica de MadridRan2013 to 2014Enrolled60ConditionsQuality of LifeArmsExercise Intervention
NCT03860740 completednot on this mapstarted 2016, after this paper: background citation

Effect of Physical Exercise on Ki-67 Levels in Women With Operable Breast Cancer Hormonal Receptor Positive, HER2 Negative

TypeobservationalSponsorSpanish Breast Cancer Research GroupRan2016 to 2021Enrolled12ConditionsBreast Cancer, Luminal BArmsExercise, Stretching
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 9 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
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  4. Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
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  6. A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Survivorship: healthy lifestyles, version 2.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014
    Guideline
  10. Trial
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  18. Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026
    Review
  19. Review
  20. Observational

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Allison S BetofDuke Cancer Institute, Durham, NC 27710, USA.
Mark W Dewhirst
Lee W Jones
Duke Cancer InstituteDuke Medical Center · US

Funding

Heat And Radiation Effects On Tumor MicrocirulationR01CA040355 · NCI · DUKE UNIVERSITY · PI DEWHIRST, MARK WESLEY · 1985 to 2013
$4.5M
Randomized Trial of Optimal Type of Aerobic Training in Breast CancerR01CA142566 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2017
$2.7M
Phase III Trial of Exercise Training in Postsurgical Lung CancerR01CA138624 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2009 to 2013
$2.1M
Synergistically Acting Targeted Therapeutics for MelanomaR01CA138634 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERTSON, GAVIN P. · 2010 to 2014
$1.5M
Phase II Trial of Aerobic Training in Metastatic Breast CancerR21CA143254 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2012
$536k
Exercise Training, Erectile Dysfunction, and Prostate CancerR21CA133895 · NCI · DUKE UNIVERSITY · PI JONES, LEE W · 2009 to 2011
$503k
Using Message Framing to Promote Physical Activity in Colorectal Cancer SurvivorsR21CA125458 · NCI · DUKE UNIVERSITY · PI JONES, LEE W · 2008 to 2009
$421k
NCI NIH HHS CA125458NCI NIH HHS CA133895NCI NIH HHS CA138634NCI NIH HHS CA142566NCI NIH HHS CA143254NCI NIH HHS CA40355NCI NIH HHS R01 CA040355NCI NIH HHS R01 CA138624NCI NIH HHS R01 CA138634NCI NIH HHS R01 CA142566NCI NIH HHS R21 CA125458NCI NIH HHS R21 CA133895NCI NIH HHS R21 CA143254
6 · The paper itself

Abstract

Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.

Indexed as

Exercise TherapyPhysical Conditioning, AnimalAnimalsDisease ProgressionHumansMiceNeoplasmsPrognosisTreatment Outcome

Identifiers

PMID22610066
PMCPMC3638811
OpenAlexW2122518264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.