ArticleJournal of bone and mineral metabolism2012
Low-energy diaphyseal femoral fractures associated with bisphosphonate use and severe curved femur: a case series.
Article in Journal of bone and mineral metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Medical Management of Patients After Atypical Femur Fractures: a Systematic Review and Recommendations From the European Calcified Tissue Society.The Journal of clinical endocrinology and metabolism · 2020Guideline
- Delayed healing of lower limb fractures with bisphosphonate therapy.Annals of the Royal College of Surgeons of England · 2015Pooled it
- Comparison of the radiographic outcomes and total blood loss between pinless navigation and conventional method in minimally invasive total knee arthroplasty.Journal of orthopaedic surgery and research · 2023Trial
- [Interpretation of the 2025 Asian Federation of Osteoporosis Societies (AFOS) Clinical Consensus: Atypical femoral fractures in patients with osteoporosis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Radius of proximal femur curvature as a significant predictor for long stem-canal match in total hip arthroplasty: a retrospective cohort study.BMC musculoskeletal disorders · 2026Article
- Asian Federation of Osteoporosis Societies 2025 consensus on atypical femoral fractures in patients with osteoporosis.Osteoporosis and sarcopenia · 2025Review
- Article
- Age- and Gender-Related Femoral Bowing Analysis in the Korean Population and Features for Clinical Applications.Medicina (Kaunas, Lithuania) · 2024Article
- Factors Affecting the Second Complete Atypical Femoral Fracture after the First Atypical Fracture.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Risk Factors Associated with Intraoperative Iatrogenic Fracture in Patients Undergoing Intramedullary Nailing for Atypical Femoral Fractures with Marked Anterior and Lateral Bowing.Medicina (Kaunas, Lithuania) · 2023Article
- Incomplete Atypical Femoral Fracture With Severe Bowing Treated by Intramedullary Nail and Corrective Osteotomy.Cureus · 2023Article
- The role of the fracture liaison service in the prevention of atypical femoral fractures.Therapeutic advances in musculoskeletal disease · 2023Review
- Acute Reconstruction of Traumatic Zone IV Re-tear of Extensor Hallucis Longus Tendon using Extensor Hallucis Brevis loop Technique - A Mid-term Follow-up Case Report.Journal of orthopaedic case reports · 2022Article
- A Rare Case of an Intertrochanteric Hip Fracture Combined with an Ipsilateral Incomplete Atypical Femoral Fracture Treated with a Long Gamma Intramedullary Nail.Journal of orthopaedic case reports · 2022Article
- Association of atypical femoral fracture location and lower limb mechanical axis: a computed tomography-based finite element analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Biomechanical analysis of the correlation between mid-shaft atypical femoral fracture (AFF) and axial varus deformation.Journal of orthopaedic surgery and research · 2022Article
- Incomplete Atypical Femoral Fracture Treated by Prophylactic Intramedullary Nail Fixation: A Case Series.Cureus · 2022Article
- Intramedullary Nailing for Atypical Femoral Fracture With Lateral Bowing: Does Medial Gap Matter?Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Differences in femur geometry and bone markers in atypical femur fractures and the general population.Scientific reports · 2021Article
- Atypical Femoral Fracture in a Patient without Bisphosphonate or Denosumab Exposure-A Case Report.Journal of orthopaedic case reports · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports have raised concerns about low-energy subtrochanteric and diaphyseal femoral fractures after long-term bisphosphonate treatment, which may be associated with severely suppressed bone turnover (SSBT). However, diaphyseal femoral fractures without bisphosphonate treatment have also been reported in patients with severely curved femur, which are commonplace in the elderly. The purpose of this study was therefore to investigate associations between occurrence of such fractures, bisphosphonate use, and curvature of the femur. Nine consecutive elderly patients treated for low-energy diaphyseal femoral fractures between 2005 and 2010 were retrospectively reviewed. Three patients sustained bilateral fractures. Eight patients were administered bisphosphonates and one patient was administered raloxifene. Duration of osteoporosis treatment, type of fractures, surgical procedure, cortical thickness and curvature of opposite femur were evaluated. The cortical thickness and femoral curvature were further compared with those of 24 control subjects without fractures. The mean duration of drug administration was 3.6 years. All fractures showed similar X-ray patterns of simple transverse fracture with medial spike. Only one femur showed thickening of the femoral cortex. One case was treated with locking plate fixation, while the other cases were operated with intramedullary nails (9 antegrade nails, 2 retrograde nails). One femur treated with retrograde nail showed delayed bone union. The femoral curvature was significantly higher in the low-energy fracture group than the control group (P < 0.01); however, cortical thickness did not show a significant difference between the groups. In addition to SSBT, increased femoral curvature might be a causative factor for low-energy diaphyseal femoral fracture in the elderly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.