ArticleAsian journal of andrology2012
Chronic stress induces ageing-associated degeneration in rat Leydig cells.
Article in Asian journal of andrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Chronic Stress Destabilizes Ectoplasmic Specialization Dynamics in the Rat Testis via Downregulating the Focal Adhesion Kinase-Associated Protein Complex.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Influence of psychosocial work factors on male fertility and sperm quality: a scoping review.Reproductive biology and endocrinology : RB&E · 2025Article
- Beta(β)-sitosterol attenuates Chronic Unpredictable Stress (CUS) Induced Testicular Damage in the Experimental Rat Model.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Perspectives on biomarkers of reproductive aging for fertility and beyond.Nature aging · 2024Review
- Growth differentiation factor 11 alleviates oxidative stress-induced senescence of endothelial progenitor cells via activating autophagy.Stem cell research & therapy · 2024Article
- Article
- Molecular phenotyping of domestic cat (Theriogenology wild · 2023Article
- Review
- Chronic stress impairs male spermatogenesis function and Nectin-3 protein expression in the testis.Physiological research · 2020Article
- Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway.Scientific reports · 2017Article
- Bisphenol A-induced ultrastructural changes in the testes of common marmoset.The Indian journal of medical research · 2017Article
- Leydig cell aging and hypogonadism.Experimental gerontology · 2015Review
- Immediate and late effects of chronic stress in the testes of prepubertal and adult rats.Asian journal of andrologyArticle
- 11β-hydroxysteroid dehydrogenase types 1 and 2 in postnatal development of rat testis: gene expression, localization and regulation by luteinizing hormone and androgens.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Several studies have suggested that stress and ageing exert inhibitory effects on rat Leydig cells. In a pattern similar to the normal process of Leydig cell ageing, stress-mediated increases in glucocorticoid levels inhibit steroidogenic enzyme expression that then results in decreased testosterone secretion. We hypothesized that chronic stress accelerates the degenerative changes associated with ageing in Leydig cells. To test this hypothesis, we established a model of chronic stress to evaluate stress-induced morphological and functional alterations in Brown Norway rat Leydig cells; additionally, intracellular lipofuscin levels, reactive oxygen species (ROS) levels and DNA damage were assessed. The results showed that chronic stress accelerated ageing-related changes: ultrastructural alterations associated with ageing, cellular lipofuscin accumulation, increased ROS levels and more extensive DNA damage were observed. Additionally, testosterone levels were decreased. This study sheds new light on the idea that chronic stress contributes to the degenerative changes associated with ageing in rat Leydig cells in vivo.
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Registered trials
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