ArticleNanotechnology2012
Chemical recognition and binding kinetics in a functionalized tunnel junction.
Article in Nanotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Fingerprint Recognition Based on Molecular-Scale Conductance Response via Electrochemically Gated Quantum Tunnelling.Sensors (Basel, Switzerland) · 2026Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges.Precision chemistry · 2024Review
- Machine learning empowered next generation DNA sequencing: perspective and prospectus.Chemical science · 2024Review
- Methods for the analysis, interpretation, and prediction of single-molecule junction conductance behaviour.Chemical science · 2024Review
- Role of contacts in long-range protein conductance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Solid-state nanopore localization by controlled breakdown of selectively thinned membranes.Nanotechnology · 2017Article
- Classification of DNA nucleotides with transverse tunneling currents.Nanotechnology · 2017Article
- Electronic single-molecule identification of carbohydrate isomers by recognition tunnelling.Nature communications · 2016Article
- Unsupervised vector-based classification of single-molecule charge transport data.Nature communications · 2016Article
- The promises and challenges of solid-state sequencing.Nature nanotechnology · 2016Article
- Electrophoretic Deformation of Individual Transfer RNA Molecules Reveals Their Identity.Nano letters · 2016Article
- Physical model for recognition tunneling.Nanotechnology · 2015Article
- Fixed-gap tunnel junction for reading DNA nucleotides.ACS nano · 2014Article
- Single-molecule spectroscopy of amino acids and peptides by recognition tunnelling.Nature nanotechnology · 2014Article
- Article
- Palladium electrodes for molecular tunnel junctions.Nanotechnology · 2012Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
4(5)-(2-mercaptoethyl)-1H-imidazole-2-carboxamide is a molecule that has multiple hydrogen bonding sites and a short flexible linker. When tethered to a pair of electrodes, it traps target molecules in a tunnel junction. Surprisingly large recognition-tunneling signals are generated for all naturally occurring DNA bases A, C, G, T and 5-methyl-cytosine. Tunnel current spikes are stochastic and broadly distributed, but characteristic enough so that individual bases can be identified as a tunneling probe is scanned over DNA oligomers. Each base yields a recognizable burst of signal, the duration of which is controlled entirely by the probe speed, down to speeds of 1 nm s -1, implying a maximum off-rate of 3 s -1 for the recognition complex. The same measurements yield a lower bound on the on-rate of 1 M -1 s -1. Despite the stochastic nature of the signals, an optimized multiparameter fit allows base calling from a single signal peak with an accuracy that can exceed 80% when a single type of nucleotide is present in the junction, meaning that recognition-tunneling is capable of true single-molecule analysis. The accuracy increases to 95% when multiple spikes in a signal cluster are analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.