ReviewThe Lancet. Neurology2012
The non-fluent/agrammatic variant of primary progressive aphasia.
Review in The Lancet. Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Noninvasive Brain Stimulation in Primary Progressive Aphasia with and Without Concomitant Speech and Language Therapy: Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Task-Free Functional Language Networks: Reproducibility and Clinical Application.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Pooled it
- A multi-modal approach for the treatment of non-fluent/agrammatic variant of Primary Progressive Aphasia.Brain communications · 2025Trial
- Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study.Brain and language · 2016Trial
- 2 mA is NOT 2 mA: Electric field variability in high-definition tDCS and its implications for precision neuromodulation in aging.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Neuropathology-specific language features in primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Beyond language: A structured profile of number processing impairment in logopenic primary progressive aphasia.Journal of Alzheimer's disease : JAD · 2026Article
- Reported symptoms and patterns of language impairment in bilingual speakers with primary progressive aphasia: a retrospective study.Aphasiology · 2026Article
- Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Written picture descriptions distinguish variants of primary progressive aphasia.Journal of Alzheimer's disease : JAD · 2025Article
- Neurological update: speech.Journal of neurology · 2025Article
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- RETRACTED: Idea Density and Grammatical Complexity as Neurocognitive Markers.Brain sciences · 2025Review
- Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia.Journal of neurology · 2025Article
- Psycholinguistic Variables and Spelling Accuracy for People with Logopenic Variant Primary Progressive Aphasia: A Cross-Sectional Study.Aphasiology · 2025Article
- Picture Description and Functional Communication Rating Correlates in Variants of Primary Progressive Aphasia.Aphasiology · 2025Article
- Safety and Efficacy of Different Therapeutic Interventions for Primary Progressive Aphasia: A Systematic Review.Journal of clinical medicine · 2025Review
- Primary Progressive Aphasias: Diagnosis and Treatment.Brain sciences · 2025Review
- Investigating changes in connected speech in nonfluent/agrammatic primary progressive aphasia following script training.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The non-fluent/agrammatic variant of primary progressive aphasia (naPPA) is a young-onset neurodegenerative disorder characterised by poor grammatical comprehension and expression and a disorder of speech sound production. In an era of disease-modifying treatments, the identification of naPPA might be an important step in establishing a specific cause of neurodegenerative disease. However, difficulties in defining the characteristic language deficits and heterogeneity in the anatomical distribution of disease in naPPA have led to controversy. Findings from imaging studies have linked an impairment of this uniquely human language capacity with disruption of large-scale neural networks centred in left inferior frontal and anterior superior temporal regions. Accordingly, the pathological burden of disease in naPPA is anatomically focused in these regions. Most cases of naPPA are associated with the spectrum of pathological changes found in frontotemporal lobar degeneration involving the microtubule-associated protein tau. Knowledge of these unique clinical-pathological associations should advance care for patients with this important class of neurodegenerative diseases while supplementing our knowledge of human cognitive neuroscience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.