Evidence map›Paper›PMID 22608666›Full record

ReviewThe Lancet. Neurology2012

Diabetic neuropathy: clinical manifestations and current treatments.

Brian C Callaghan, Hsinlin T Cheng, Catherine L Stables, Andrea L Smith, Eva L Feldman

6 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 551 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
551citing papers in PubMed, 13 pooled it
31.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04088929 phase2completednot on this mapstarted 2019, after this paper: background citation

A Dose Controlled Diabetic Neuropathic Pain Study Using Non-Intoxicating Cannabidiol in a Rapidly Dissolvable Sublingual Tablet

TypeinterventionalSponsorPure GreenRan2019 to 2019Enrolled32ConditionsDiabetic NeuropathiesArmsCBD
NCT04467255 nacompletednot on this mapstarted 2018, after this paper: background citation

Muscular Fatigue Evaluation in Patients With Diabetic Neuropathy by Means of Multichannel Surface Electromyography After a Rehabilitative Training: Aerobic Versus Endurance Training.

TypeinterventionalSponsorIstituti Clinici Scientifici Maugeri SpARan2018 to 2024Enrolled30ConditionsNeuropathy, Diabetes MellitusArmsRehabilitative training
NCT04679545 phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

A Randomized, Double-Blind, Placebo-Controlled Trial Using Cannabidiol for the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet

TypeinterventionalSponsorPure GreenRan2020 to 2021Enrolled50ConditionsDiabetic Peripheral Neuropathic PainArmsCBD, Placebo
NCT05422352 nacompletednot on this mapstarted 2021, after this paper: background citation

Role of Carnosine in Combination With Vitamin B Complex in Preventing the Progression of Diabetic Neuropathy in Type 2 Diabetes Patients

TypeinterventionalSponsorBeni-Suef UniversityRan2021 to 2022Enrolled60ConditionsDiabetic NeuropathiesArmsCarnosine
NCT05766969 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized, Double-Blind, Placebo-Controlled Trial Using Cannabidiol and Palmitoylethanolamide for the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet

TypeinterventionalSponsorPure Green Pharmaceuticals Inc.Ran2023 to 2023Enrolled52ConditionsDiabetic Peripheral Neuropathic PainArmsCBD/PEA, Placebo
NCT07734597 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Serum Irisin Levels as a Potential Biomarker in Patients With Diabetic Polyneuropathy: A Single-center Prospective Cross-sectional Observational Study

Typeobservational_patient_registrySponsorGÜLDEN ANATACARan2026 to 2026Enrolled81ConditionsPolyneuropathies, Diabetic Complications Neurological, Diabetes Mellitus Type 2
3 · Its place in the literature

Who cites it

551 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,148 citations in OpenAlex.

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  10. Alpha-lipoic acid for diabetic peripheral neuropathy.The Cochrane database of systematic reviews · 2024
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491 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brian C CallaghanUniversity of Michigan, Ann Arbor, MI, USA. bcallagh@med.umich.edu
Hsinlin T Cheng
Catherine L Stables
Andrea L Smith
Eva L Feldman
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Integrated Systems Biology Approach to Diabetic Microvascular ComplicationsR24DK082841 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, BROSIUS, FRANK C · 2008 to 2020
$13.1M
Tissue-Specific Metabolic Reprogramming in Diabetic ComplicationsDP3DK094292 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C, BURANT, CHARLES F · 2011 to 2011
$5.5M
Nerve Growth Factor Signaling in Painful Diabetic NeuropathyK08NS061039 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHENG, HSINLIN THOMAS · 2009 to 2013
$881k
NIDDK NIH HHS 1 DP3 DK094292NIDDK NIH HHS 1 R24 DK082841NIDDK NIH HHS DP3 DK094292NIDDK NIH HHS R24 DK082841NINDS NIH HHS K08 NS061039NINDS NIH HHS K08 NS061039-01A2A
6 · The paper itself

Abstract

Diabetic peripheral neuropathy is a prevalent, disabling disorder. The most common manifestation is distal symmetrical polyneuropathy (DSP), but many patterns of nerve injury can occur. Currently, the only effective treatments are glucose control and pain management. While glucose control substantially decreases the development of neuropathy in those with type 1 diabetes, the effect is probably much smaller in those with type 2 diabetes. Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. However, the lack of disease-modifying therapies for diabetic DSP makes the identification of new modifiable risk factors essential. Growing evidence supports an association between components of the metabolic syndrome, including prediabetes, and neuropathy. Studies are needed to further explore this association, which has implications for the development of new treatments for this common disorder.

Indexed as

Diabetic NeuropathiesHumansRisk Factors

Identifiers

PMID22608666
PMCPMC4254767
OpenAlexW2101099639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.