Trial reportThe Journal of allergy and clinical immunology2012
Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.
Trial report in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment.The pharmacogenomics journal · 2017Trial
- Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.The Journal of allergy and clinical immunology · 2015Trial
- A randomized comparison of intramuscular high-dose versus oral maintenance vitamin D to prevent severe exacerbations in deficient/insufficient asthmatic children.The journal of allergy and clinical immunology. Global · 2025Article
- Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure.International forum of allergy & rhinology · 2025Article
- Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches.International journal of molecular sciences · 2024Review
- Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper.Clinical and translational allergy · 2020Review
- Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma.BMC pediatrics · 2019Article
- A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence.Frontiers in pharmacology · 2019Article
- Asthma and Medicines - Long-Term Side-Effects, Monitoring and Dose Titration.Indian journal of pediatrics · 2018Review
- Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice.Canadian respiratory journal · 2018Article
- Dietary 2-oxoglutarate prevents bone loss caused by neonatal treatment with maximal dexamethasone dose.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Benefits and Risks of Long-Term Asthma Management in Children: Where Are We Heading?Drug safety · 2017Review
- Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.PloS one · 2017Article
- Glucocorticoid-induced osteoporosis: pathophysiological role of GH/IGF-I and PTH/VITAMIN D axes, treatment options and guidelines.Endocrine · 2016Article
- Adequate Vitamin D Intake but Low Serum Levels in Pediatric Asthma Patients: A Pilot Study, Alberta Children's Hospital.Canadian respiratory journal · 2016Article
- Food insecurity, vitamin D insufficiency and respiratory infections among Inuit children.International journal of circumpolar health · 2016Article
- Vitamin D and Asthma: Association, Causality, or Intervention?Pediatric allergy, immunology, and pulmonology · 2015Article
- Genetic variation in Ameloblastin is associated with caries in asthmatic children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2014Article
- Plasma exchange induces vitamin D deficiency.QJM : monthly journal of the Association of Physicians · 2014Article
- 25-Hydroxyvitamin D3-deficiency enhances oxidative stress and corticosteroid resistance in severe asthma exacerbation.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been associated with decreased bone mineral density (BMD).
objectiveWe sought to determine whether children with asthma who have lower vitamin D levels are more susceptible to the negative effects of corticosteroids on BMD over time.
methodsChildren aged 5 to 12 years with mild-to-moderate asthma who participated in the Childhood Asthma Management Program were followed for a mean of 4.3 years. Total doses of inhaled corticosteroids and oral corticosteroids (OCSs) were recorded, serum 25-hydroxyvitamin D3 levels were measured at the beginning of the trial, and serial dual-energy x-ray absorptiometry scans of the lumbar spine were performed. Annual BMA rates were defined as follows: [(BMD at 4 years' follow-up - BMD at baseline)/4 years].
resultsBMA was calculated for 780 subjects. In boys baseline vitamin D levels significantly modified the relationship between OCSs and BMA (vitamin D × OCS interaction, P= .023). Stratification by vitamin D levels showed a decrease in BMA with increased use of OCSs in vitamin D-insufficient boys only (P< .001). Compared with vitamin D-sufficient boys, vitamin D-insufficient boys exposed to more than 2 courses of OCSs per year had twice the decrease in BMA rate (relative to boys who were OCS unexposed).
conclusionsVitamin D levels significantly modified the effect of OCSs on BMA in boys. Further research is needed to examine whether vitamin D supplementation in children with poorly controlled asthma might confer benefits to bone health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.