ArticleEpilepsy research2012
Variability of sclerosis along the longitudinal hippocampal axis in epilepsy: a post mortem study.
Article in Epilepsy research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.JAMA neurology · 2024Article
- Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis.Brain structure & function · 2024Article
- Longitudinal hippocampal diffusion-weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy.Epilepsia open · 2023Article
- Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy.Frontiers in cell and developmental biology · 2022Review
- Review: Neuropathology findings in autonomic brain regions in SUDEP and future research directions.Autonomic neuroscience : basic & clinical · 2021Review
- Curved multiplanar reformatting provides improved visualization of hippocampal anatomy.Hippocampus · 2020Article
- Common Principles in Functional Organization of VIP/Calretinin Cell-Driven Disinhibitory Circuits Across Cortical Areas.Frontiers in neural circuits · 2020Review
- Histological correlates of hippocampal magnetization transfer images in drug-resistant temporal lobe epilepsy patients.NeuroImage. Clinical · 2020Article
- Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy.Frontiers in neurology · 2020Article
- Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways.Frontiers in cellular neuroscience · 2020Article
- Trajectories of brain remodeling in temporal lobe epilepsy.Journal of neurology · 2019Article
- Regional hippocampal diffusion abnormalities associated with subfield-specific pathology in temporal lobe epilepsy.Epilepsia open · 2019Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
- Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy.The Journal of comparative neurology · 2017Article
- Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations.NeuroImage · 2015Article
- Hippocampal sclerosis in feline epilepsy.Brain pathology (Zurich, Switzerland) · 2014Article
- In vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology.Human brain mapping · 2014Article
- Review: Hippocampal sclerosis in epilepsy: a neuropathology review.Neuropathology and applied neurobiology · 2014Review
- Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.Neurobiology of disease · 2014Article
- A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia.Neuropathology and applied neurobiology · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Detailed neuropathological studies of the extent of hippocampal sclerosis (HS) in epilepsy along the longitudinal axis of the hippocampus are lacking. Neuroimaging studies of patients with temporal lobe epilepsy support that sclerosis is not always localised. The extent of HS is of relevance to surgical planning and poor outcomes may relate to residual HS in the posterior remnant. In 10 post mortems from patients with long histories of drug refractory epilepsy and 3 controls we systematically sampled the left and right hippocampus at seven coronal anatomical levels along the body to the tail. We quantified neuronal densities in CA1 and CA4 subfields at each level using Cresyl Violet (CV), calretinin (CR), calbindin (CB) and Neuropeptide Y (NPY) immunohistochemistry. In the dentate gyrus we graded the extent of granule cell dispersion, patterns of CB expression, and synaptic reorganisation with CR and NPY at each level. We identified four patterns of HS based on patterns of pyramidal and interneuronal loss and dentate gyrus reorganisation between sides and levels as follows: (1) symmetrical HS with anterior-posterior (AP) gradient, (2) symmetrical HS without AP gradient, (3) asymmetrical HS with AP gradient and (4) asymmetrical cases without AP gradient. We confirmed in this series that HS can extend into the tail. The patterns of sclerosis (classical versus atypical or none) were consistent between all levels in less than a third of cases. In conclusion, this series highlights the variability of HS along the longitudinal axis. Further studies are required to identify factors that lead to focal versus diffuse HS.
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