ArticleAmerican heart journal2012
Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines.
Article in American heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Guideline
- Epidemiology of infective endocarditis beforeTherapeutic advances in cardiovascular diseasePooled it
- 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology.Arquivos brasileiros de cardiologiaGuideline
- In-hospital Outcomes of Pediatric Cardiac Surgery Admissions for Acute Infective Endocarditis in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.Dentistry journal · 2025Review
- Infective Endocarditis at a Referral Children's Hospital During 19-Year Period: Trends and Outcomes.Pediatric cardiology · 2024Article
- Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology - 2024.Arquivos brasileiros de cardiologia · 2024Article
- Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Infective Endocarditis among Pediatric Patients with Prosthetic Valves and Cardiac Devices: A Review and Update of Recent Emerging Diagnostic and Management Strategies.Journal of clinical medicine · 2023Review
- Neurologic complications of infective endocarditis in children.Cardiology in the young · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Pathogenesis and distribution of infective endocarditis in the pediatric population: a 20-year experience in a tertiary care center in a developing country.Frontiers in cardiovascular medicine · 2023Article
- Infective endocarditis by HACEK: a review.Journal of cardiothoracic surgery · 2022Review
- Infective endocarditis and oral health-a Narrative Review.Cardiovascular diagnosis and therapy · 2021Review
- Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years.Brazilian journal of cardiovascular surgery · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Endocarditis prophylaxis in daily practice of pediatricians and dentists in Flanders.European journal of pediatrics · 2021Article
- Microbiological and Clinicoepidemiological Profile of a Series of Patients with Infective Endocarditis at a Center in Eastern Nepal.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn 2007, the American Heart Association recommended cessation of antibiotic prophylaxis for infective endocarditis (IE) before dental procedures for all but those at highest risk for adverse outcomes from IE. The impact of these guidelines is unclear. We evaluated IE hospitalizations at US children's hospitals during this period.
methodsChildren <18 years old hospitalized from 2003 to 2010 with IE at 37 centers in the Pediatric Health Information Systems Database were included. Using Poisson regression, we evaluated the number IE hospitalizations over time (raw and indexed to total hospital admissions).
resultsA total of 1157 IE cases were identified; 68% had congenital heart disease (CHD). The raw number of IE cases did not change significantly over time (+1.6% difference post vs pre guidelines, 95% CI -6.4% to +10.3%, P = .7). When the number of IE cases was indexed per 1,000 hospital admissions, there was a significant decline during the time period before the guidelines (annual change: -5.9%, 95% CI -9.9 to -1.8, P = .005) and a similar decline in the post guidelines period such that the difference between the 2 periods was not significant (P = .15). In subgroup analysis, no significant change over time in IE cases (raw or indexed) was found in the CHD subset, those 5 to 18 years old (subgroup most likely receiving dental care), or in cases coded as oral streptococci.
conclusionsWe found no evidence that release of new antibiotic prophylaxis guidelines was associated with a significant change in IE admissions across 37 US children's hospitals.
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