Trial reportThe international journal of neuropsychopharmacology2013
Dopamine D4 receptor gene variation is associated with context-dependent attention for emotion stimuli.
Trial report in The international journal of neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans.Frontiers in behavioral neuroscience · 2020Article
- Attentional biases to emotional stimuli: Key components of the RDoC constructs of sustained threat and loss.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- DRD4 long allele carriers show heightened attention to high-priority items relative to low-priority items.Journal of cognitive neuroscience · 2015Article
- Dopamine receptor D4 (DRD4) gene modulates the influence of informational masking on speech recognition.Neuropsychologia · 2015Article
- Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children.Appetite · 2014Article
- Dopamine D4 receptors in psychostimulant addiction.Advances in pharmacology (San Diego, Calif.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Dopamine D(4) receptor (DRD4) gene variation has been associated with biased attention for contextually relevant information (e.g. images of cigarettes among smokers). No research has examined whether DRD4 variation is associated with biased attention for contextually cued emotion stimuli, an important putative intermediate phenotype for a number of pathologies (e.g. depression and anxiety). We conducted two studies examining the relationship between the DRD4 variable number tandem repeats polymorphism and attention bias for facial expressions of emotion following a mood-state manipulation in healthy young adult samples. Study 1 demonstrated that long (i.e. seven or greater tandem repeats) DRD4 allele carriers vs. short DRD4 homozygotes had increased attention for sad facial stimuli, but only after a sad mood provocation. Study 2 demonstrated an association between the long DRD4 allele and attention for negative stimuli (sad and fear expressions) following a sad mood provocation. These studies are the first to demonstrate an association between the long DRD4 allele and biased attention for contextually cued emotion stimuli, an important cognitive mechanism thought to increase risk for affective psychopathology. Implications of these studies for vulnerability and plasticity models of psychiatric genetics are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.