ReviewTrends in parasitology2012
Levamisole receptors: a second awakening.
Review in Trends in parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
- Neuropharmacology of levamisole and its phase I metabolites: lack of evidence for levamisole-cocaine interactions.Psychopharmacology · 2026Article
- A novel anaerobic cholinergic signaling compound, β-alanine betaine, and nAChRs in Ascaris.PLoS neglected tropical diseases · 2026Article
- β-alanine betaine and nAChRs inbioRxiv : the preprint server for biology · 2026Article
- CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae.Nature communications · 2026Article
- Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes.Acta parasitologica · 2026Article
- Spathulenol, a Sesquiterpene fromACS omega · 2026Article
- The volatile anesthetic isoflurane causes global suppression of neuronal activity, disrupting hub neuron function inFrontiers in systems neuroscience · 2026Article
- Article
- Levamisole as a Strategy Against Bacteria from Canine Otitis Externa: An In Vitro Evaluation.Veterinary sciences · 2025Article
- Nematicidal Effects and Cytotoxicity of Levamisole onAnimals : an open access journal from MDPI · 2025Article
- The effect of common paralytic agents used for fluorescence imaging on redox tone and ATP levels in Caenorhabditis elegans.PloS one · 2024Article
- The potential immunomodulatory effect of levamisole in humans and farm animals.Journal of advanced veterinary and animal research · 2023Review
- Novel combination therapy for respiratory diseases of small ruminants: Field studies of over 10 years.Journal of advanced veterinary and animal research · 2023Article
- Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus.International journal for parasitology. Drugs and drug resistance · 2022Article
- Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites.PLoS pathogens · 2022Article
- Article
- Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans.International journal for parasitology. Drugs and drug resistance · 2021Article
- Action of Carvacrol onPharmaceuticals (Basel, Switzerland) · 2021Article
- Anthelmintic Resistance and Its Mechanism: A Review.Infection and drug resistance · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Levamisole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylcholine ion channel receptors; they are used to treat roundworm infections in humans and animals. Interest in their actions has surged, giving rise to new knowledge and technical advances, including an ability to reconstitute receptors that reveal more details of modes of action/resistance. We now know that the receptors are plastic and may form diverse species-dependent subtypes of receptor with different sensitivities to individual cholinergic anthelmintics. Understanding the biology of the levamisole receptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on ion channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.