ArticleRejuvenation research2012
Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults.
Article in Rejuvenation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Genetic Factors Affecting Late-Onset Alzheimer's Disease Susceptibility.Neuromolecular medicine · 2016Article
- Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.Biogerontology · 2015Article
- MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus.Neurobiology of aging · 2015Article
- Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.International journal of clinical and experimental pathology · 2014Review
- Genomics and successful aging: grounds for renewed optimism?The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- The genetics of age-related health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
introductionCirculating inflammatory markers may play an important role in cognitive impairment at older ages. Mice deficient for the chemokine (C-C motif) receptor 2 (CCR2) develop an accelerated Alzheimer-like pathology. CCR2 is also important in neurogenesis. To identify human gene transcripts most closely associated with Mini-Mental State Examination (MMSE) scores, we undertook a genome-wide and inflammation specific transcriptome screen in circulating leukocytes from a population-based sample.
methodsWe measured in vivo transcript levels by microarray analysis in 691 subjects (mean age 72.6 years) in the InCHIANTI study (Invecchiare in Chianti, aging in the Chianti area). We assessed expression associations with MMSE performance at RNA collection and prior 9-year change in MMSE score in linear regression models.
resultsIn genome-wide analysis, raised CCR2 expression was cross-sectionally the most strongly associated transcript with lower MMSE score (beta=-0.16, p=5.1×10(-6), false discovery rate (FDR; q=0.077). Amongst inflammatory transcripts, only CCR2 expression was associated with both MMSE score and accelerated decline in score over the preceding 9 years (beta=-0.16, p=5.1×10(-6), q=0.003; and beta=-0.13, p=5.5×10(-5), q=0.03, respectively). CCR2 expression was also positively associated with apolipoprotein E (ApoE) e4 Alzheimer disease risk haplotype.
conclusionsWe show for the first time that CCR2 expression is associated with lower MMSE scores in an older human population. Laboratory models of Ccr2-mediated β-amyloid removal and regulation of neurogenesis affecting cognitive function may be applicable in humans. CCR2-mediated pathways may provide a possible focus for intervention to potentiate protective reactions to Alzheimer pathology in older people, including for people with an adverse ApoE haplotype.
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