ArticleBMC complementary and alternative medicine2012
Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent.
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 50 citations in OpenAlex.
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- A review on anti-peptic ulcer activities of medicinal plants used in the formulation ofHeliyon · 2021Review
- Protective Effect ofAntioxidants (Basel, Switzerland) · 2021Article
- Microbial lipases and their industrial applications: a comprehensive review.Microbial cell factories · 2020Review
- Evaluation of antioxidant activities and essential/toxicmetal levels and their health risk assessment in citrus fruits from Pakistan.Environmental monitoring and assessment · 2019Article
- Herbal medicine use during breastfeeding: a cross-sectional study among mothers visiting public health facilities in the Western area of Sierra Leone.BMC complementary and alternative medicine · 2019Article
- Gastroprotective Effects of Plants Extracts on Gastric Mucosal Injury in Experimental Sprague-Dawley Rats.BioMed research international · 2019Article
- Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.Inflammopharmacology · 2018Article
- Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.Molecules (Basel, Switzerland) · 2018Review
- ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Review
- Protective effects of Weilikang decoction on gastric ulcers and possible mechanisms.Journal of natural medicines · 2016Article
- Article
- Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.PloS one · 2015Article
- Exploiting the phenomenal anti-ulcerogenic potential of Talinum portulacifolium ethanolic extract whole plant on Albino Rats: The therapeutic potential of Chinese Herb-mǎ chǐ xiàn kē (Portulacaceae).Pharmacognosy research · 2014Article
- Gastroprotective effects of combination of hot water extracts of turmeric (Curcuma domestica L.), cardamom pods (Ammomum compactum S.) and sembung leaf (Blumea balsamifera DC.) against aspirin-induced gastric ulcer model in rats.Asian Pacific journal of tropical biomedicine · 2014Article
- Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Anti-ulcerogenic activity of the root bark extract of the African laburnum "Cassia sieberiana" and its effect on the anti-oxidant defence system in rats.BMC complementary and alternative medicine · 2012Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCassia sieberiana is a savannah tree with a wide phytotherapeutic application including the use of its roots in the management of various stomach disorders including gastric ulcer, stomach pains and indigestion. The aim of the study is to evaluate the antioxidant, gastric cytoprotective prostaglandins, secretory phospholipase A2, phytochemical and acute toxicity properties of Cassia sieberiana roots bark extract in a bid to justify its phytotherapeutic applications in gastric ulcer.
methodsAntioxidant and radical scavenging activities of the roots bark extract of Cassia sieberiana were assayed. Serum secretory phospholipase A2 (sPLA2) concentration and activity and the formation of gastric mucosal prostaglandins E2 (PGE2) and I2 (PGI2) were also assessed. Comparisons between means were performed using analysis of variance (ANOVA) followed by Students Standard Newman-Keuls post hoc analysis to determine statistical significance. P < 0.05 was considered significant.
resultsThe extract was found to possess significant ferric reducing antioxidant power and can scavenge hydroxyl radicals. The extract also possesses DPPH scavenging activity, can chelate ferrous ion and a dose-dependent protective effect against lipid peroxidation and free radical generation. Prostaglandin studies showed that the roots bark extract dose dependently increased gastric mucosal PGE2 and PGI2 levels and also decreased serum sPLA2 activity. Phytochemical analyses suggest that the roots extract contains polyhydroxyl/phenolic substances. Acute toxicity test showed no sign of toxicity up to a dose level of 2000 mg/kg body weight p.o.
conclusionsC. sieberiana roots extract possesses significant antioxidant and gastric cytoprotective prostaglandin properties as well as serum secretory phospholipase A2 inhibitory activity which could be due to its content of polyhydroxy and/or phenolic substances. This may justify its use as an anti-ulcerogenic agent in traditional medicine in West Africa.
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