ArticleBMC genomics2012
Genetic variation and metabolic pathway intricacy govern the active compound content and quality of the Chinese medicinal plant Lonicera japonica thunb.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 104 citations in OpenAlex.
- Application of biosensors in research of traditional Chinese medicine: a systematic review.Chinese medicine · 2026Review
- Integrating transcriptome and metabolome analyses to characterize flower development in Salix variegata franch., a typical dioecious plant.Scientific reports · 2025Article
- Multi-omics integration reveals organ-specific biosynthesis of flavonoids and terpenoids in the medicinal plantFrontiers in plant science · 2025Article
- Cloning and functional verification ofPeerJ · 2025Article
- Improving seed germination: effect of stratification and dormancy-release priming inFrontiers in plant science · 2024Article
- Comparative Transcriptome Profiling Reveals Two WRKY Transcription Factors Positively Regulating Polysaccharide Biosynthesis inInternational journal of molecular sciences · 2023Article
- Genome-wide analysis of the MADS-box gene family in Lonicera japonica and a proposed floral organ identity model.BMC genomics · 2023Article
- Use of ATR-FTIR Spectroscopy and Chemometrics for the Variation of Active Components in Different Harvesting Periods ofInternational journal of analytical chemistry · 2022Article
- Quality evaluation of Lonicerae Japonicae Flos and Lonicerae Flos based on simultaneous determination of multiple bioactive constituents combined with multivariate statistical analysis.Phytochemical analysis : PCA · 2021Article
- De novo RNA sequencing and analysis reveal the putative genes involved in diterpenoid biosynthesis in3 Biotech · 2021Article
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- Regulation of chlorogenic acid, flavonoid, and iridoid biosynthesis by histone H3K4 and H3K9 methylation in Lonicera japonica.Molecular biology reports · 2020Article
- Mining genes associated with furanocoumarin biosynthesis in an endangered medicinal plant,Journal of genetics · 2020Article
- Cross-Species Annotation of Expressed Genes and Detection of Different Functional Gene Modules Between 10 Cold- and 10 Hot-Propertied Chinese Herbal Medicines.Frontiers in genetics · 2020Article
- Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations.Frontiers in pharmacology · 2020Review
- De novo transcriptomic analysis of light-induced flavonoid pathway, transcription factors in the flower buds ofTrees (Berlin, Germany : West) · 2020Article
- Comparison of Multiple Bioactive Constituents in the Flower and the Caulis ofMolecules (Basel, Switzerland) · 2019Article
- Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors.BMC plant biology · 2019Article
- Comparison of Free, Esterified, and Insoluble-Bound Phenolics and Their Bioactivities in Three Organs ofMolecules (Basel, Switzerland) · 2019Article
- Identification and evaluation ofPeerJ · 2019Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraditional Chinese medicine uses various herbs for the treatment of various diseases for thousands of years and it is now time to assess the characteristics and effectiveness of these medicinal plants based on modern genetic and molecular tools. The herb Flos Lonicerae Japonicae (FLJ or Lonicera japonica Thunb.) is used as an anti-inflammatory agent but the chemical quality of FLJ and its medicinal efficacy has not been consistent. Here, we analyzed the transcriptomes and metabolic pathways to evaluate the active medicinal compounds in FLJ and hope that this approach can be used for a variety of medicinal herbs in the future.
resultsWe assess transcriptomic differences between FLJ and L. japonica Thunb. var. chinensis (Watts) (rFLJ), which may explain the variable medicinal effects. We acquired transcriptomic data (over 100 million reads) from the two herbs, using RNA-seq method and the Illumina GAII platform. The transcriptomic profiles contain over 6,000 expressed sequence tags (ESTs) for each of the three flower development stages from FLJ, as well as comparable amount of ESTs from the rFLJ flower bud. To elucidate enzymatic divergence on biosynthetic pathways between the two varieties, we correlated genes and their expression profiles to known metabolic activities involving the relevant active compounds, including phenolic acids, flavonoids, terpenoids, and fatty acids. We also analyzed the diversification of genes that process the active compounds to distinguish orthologs and paralogs together with the pathways concerning biosynthesis of phenolic acid and its connections with other related pathways.
conclusionsOur study provides both an initial description of gene expression profiles in flowers of FLJ and its counterfeit rFLJ and the enzyme pool that can be used to evaluate FLJ quality. Detailed molecular-level analyses allow us to decipher the relationship between metabolic pathways involved in processing active medicinal compounds and gene expressions of their processing enzymes. Our evolutionary analysis revealed specific functional divergence of orthologs and paralogs, which lead to variation in gene functions that govern the profile of active compounds.
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