ArticleBMC genetics2012
Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.
Article in BMC genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Deconstruction ofbioRxiv : the preprint server for biology · 2026Article
- A complete chromosome substitution mapping panel reveals genome-wide epistasis in Arabidopsis.Heredity · 2024Article
- Epistasis for head morphology in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- The complex role of genetic background in shaping the effects of spontaneous and induced mutations.Yeast (Chichester, England) · 2021Review
- Meiotic crossover reduction by virus-induced gene silencing enables the efficient generation of chromosome substitution lines and reverse breeding in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2020Article
- Hybrid Incompatibility of the Plant Immune System: An Opposite Force to Heterosis Equilibrating Hybrid Performances.Frontiers in plant science · 2020Review
- Dissecting the eQTL Micro-Architecture inFrontiers in genetics · 2020Article
- The virtuous cycle of human genetics and mouse models in drug discovery.Nature reviews. Drug discovery · 2019Review
- Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results.BMC research notes · 2015Article
- Mendelizing all Components of a Pyramid of Three Yield QTL in Tomato.Frontiers in plant science · 2015Article
- Higher-order genetic interactions and their contribution to complex traits.Trends in genetics : TIG · 2015Review
- Article
- Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Cryptic genetic variation: evolution's hidden substrate.Nature reviews. Genetics · 2014Review
- Why epistasis is important for tackling complex human disease genetics.Genome medicine · 2014Article
- Epistasis and quantitative traits: using model organisms to study gene-gene interactions.Nature reviews. Genetics · 2014Review
- Chromosome substitution strains: gene discovery, functional analysis, and systems studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe genetic architecture of complex traits strongly influences the consequences of inherited mutations, genetic engineering, environmental and genetic perturbations, and natural and artificial selection. But because most studies are under-powered, the picture of complex traits is often incomplete. Chromosome substitution strains (CSSs) are a unique paradigm for these genome surveys because they enable statistically independent, powerful tests for the phenotypic effects of each chromosome on a uniform inbred genetic background. A previous CSS survey in mice and rats revealed many complex trait genes (QTLs), large phenotypic effects, extensive epistasis, as well as systems properties such as strongly directional phenotypic changes and genetically-determined limits on the range of phenotypic variation. However, the unusually close genetic relation between the CSS progenitor strains in that study raised questions about the impact of genetic divergence: would greater divergence between progenitor strains, with the corresponding changes in gene regulation and protein function, lead to significantly more distinctive phenotypic features, or alternatively would epistasis and systems constraints, which are pervasive in CSSs, limit the range of phenotypic variation regardless of the extent of DNA sequence variation?
resultsWe analyzed results for an extensive survey of traits in two new panels of CSSs where the donor strains were derived from inbred strains with more distant origins and discovered a strong similarity in genetic and systems properties among the three CSS panels, regardless of divergence time.
conclusionOur results argue that DNA sequence differences between host and donor strains did not substantially affect the architecture of complex traits, and suggest instead that strong epistasis buffered the phenotypic effects of genetic divergence, thereby constraining the range of phenotypic variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.