ArticleThe Analyst2012
Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine.
Article in The Analyst, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 83 citations in OpenAlex.
- Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.ECS sensors plus · 2023Review
- Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine.Analytical and bioanalytical chemistry · 2023Article
- Significance of an Electrochemical Sensor and Nanocomposites: Toward the Electrocatalytic Detection of Neurotransmitters and Their Importance within the Physiological System.ACS nanoscience Au · 2023Review
- A Novel Poly(3-hexylthiophene) Engineered Interface for Electrochemical Monitoring of Ascorbic Acid During the Occurrence of Glutamate-Induced Brain Cytotoxic Edemas.Research (Washington, D.C.) · 2023Article
- Nanostructured carbon-fiber surfaces for improved neurochemical detection.Faraday discussions · 2022Article
- Improved Serotonin Measurement with Fast-Scan Cyclic Voltammetry: Mitigating Fouling by SSRIs.Journal of the Electrochemical Society · 2022Article
- Amine-functionalized carbon-fiber microelectrodes for enhanced ATP detection with fast-scan cyclic voltammetry.Analytical methods : advancing methods and applications · 2021Article
- Review-Recent Advances in FSCV Detection of Neurochemicals via Waveform and Carbon Microelectrode Modification.Journal of the Electrochemical Society · 2021Article
- Simple and Effective Approach to Prepare an Epoxy-Functionalized Polymer and Its Application for an Electrochemical Immunosensor.ACS omega · 2021Article
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
- Polymer Modified Carbon Fiber Microelectrodes for Precision Neurotransmitter Metabolite Measurements.Journal of the Electrochemical Society · 2020Article
- Improving serotonin fast-scan cyclic voltammetry detection: new waveforms to reduce electrode fouling.The Analyst · 2020Article
- Optimization of graphene oxide-modified carbon-fiber microelectrode for dopamine detection.Analytical methods : advancing methods and applications · 2020Article
- Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems.Reviews in analytical chemistry · 2020Article
- Article
- Nanodiamond Coating Improves the Sensitivity and Antifouling Properties of Carbon Fiber Microelectrodes.ACS sensors · 2019Article
- Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection.Analytical methods : advancing methods and applications · 2019Article
- Continuous monitoring of adenosine and its metabolites using microdialysis coupled to microchip electrophoresis with amperometric detection.Analytical methods : advancing methods and applications · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adenosine is a neuromodulator that regulates neurotransmission. Adenosine can be monitored using fast-scan cyclic voltammetry at carbon-fiber microelectrodes and ATP is a possible interferent in vivo because the electroactive moiety, adenine, is the same for both molecules. In this study, we investigated carbon-fiber microelectrodes coated with Nafion and carbon nanotubes (CNTs) to enhance the sensitivity of adenosine and decrease interference by ATP. Electrodes coated in 0.05 mg mL(-1) CNTs in Nafion had a 4.2 ± 0.2 fold increase in current for adenosine, twice as large as for Nafion alone. Nafion-CNT electrodes were 6 times more sensitive to adenosine than ATP. The Nafion-CNT coating did not slow the temporal response of the electrode. Comparing different purine bases shows that the presence of an amine group enhances sensitivity and that purines with carbonyl groups, such as guanine and hypoxanthine, do not have as great an enhancement after Nafion-CNT coating. The ribose group provides additional sensitivity enhancement for adenosine over adenine. The Nafion-CNT modified electrodes exhibited significantly more current for adenosine than ATP in brain slices. Therefore, Nafion-CNT modified electrodes are useful for sensitive, selective detection of adenosine in biological samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.