ArticlePloS one2012
Vitronectin increases vascular permeability by promoting VE-cadherin internalization at cell junctions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.Nature biotechnology · 2025Article
- The Complement System.Advances in experimental medicine and biology · 2025Review
- Vitronectin Levels in the Plasma of Neuroblastoma Patients and Culture Media of 3D Models: A Prognostic Circulating Biomarker?International journal of molecular sciences · 2024Article
- The extracellular microenvironment in immune dysregulation and inflammation in retinal disorders.Frontiers in immunology · 2023Review
- Article
- IntegrinInternational journal of molecular sciences · 2021Article
- Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells.Fluids and barriers of the CNS · 2020Article
- The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer-aided detection.International journal of cancer · 2020Article
- Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2.Journal of molecular neuroscience : MN · 2019Article
- Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.Journal of cell science · 2018Article
- Src Plays an Important Role in AGE-Induced Endothelial Cell Proliferation, Migration, and Tubulogenesis.Frontiers in physiology · 2018Article
- Vitronectin and dermcidin serum levels predict the metastatic progression of AJCC I-II early-stage melanoma.International journal of cancer · 2016Article
- Disorders of Vascular Permeability.Annual review of pathology · 2016Review
- Urinary trypsin inhibitor attenuates LPS-induced endothelial barrier dysfunction by upregulation of vascular endothelial-cadherin expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers.Advances in wound care · 2015Article
- Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis.PloS one · 2015Article
- Control of vascular permeability by adhesion molecules.Tissue barriers · 2015Article
- Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism.Journal of thrombosis and haemostasis : JTH · 2014Article
- Pathogenic Rickettsia species acquire vitronectin from human serum to promote resistance to complement-mediated killing.Cellular microbiology · 2014Article
- Blocking αVβ3 integrin ligand occupancy inhibits the progression of albuminuria in diabetic rats.Journal of diabetes research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCross-talk between integrins and cadherins regulates cell function. We tested the hypothesis that vitronectin (VN), a multi-functional adhesion molecule present in the extracellular matrix and plasma, regulates vascular permeability via effects on VE-cadherin, a critical regulator of endothelial cell (EC) adhesion. METHODOLOGY/PRINCIPAL
findingsAddition of multimeric VN (mult VN) significantly increased VE-cadherin internalization in human umbilical vein EC (HUVEC) monolayers. This effect was blocked by the anti-α(V)β(3) antibody, pharmacological inhibition and knockdown of Src kinase. In contrast to mult VN, monomeric VN did not trigger VE-cadherin internalization. In a modified Miles assay, VN deficiency impaired vascular endothelial growth factor-induced permeability. Furthermore, ischemia-induced enhancement of vascular permeability, expressed as the ratio of FITC-dextran leakage from the circulation into the ischemic and non-ischemic hindlimb muscle, was significantly greater in the WT mice than in the Vn(-/-) mice. Similarly, ischemia-mediated macrophage infiltration was significantly reduced in the Vn(-/-) mice vs. the WT controls. We evaluated changes in the multimerization of VN in ischemic tissue in a mouse hindlimb ischemia model. VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking. CONCLUSION/SIGNIFICANCE: These results have important implications for the regulation of endothelial function and angiogenesis by VN under normal and pathological conditions.
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